Hypertriglyceridaemia okozta akut pancreatitis sajátosságai beteganyagunkban

Translated title of the contribution: Acute pancreatitis caused by hypertriglyceridemia

Tamás Baranyai, Viktória Terzin, Ágota Vajda, T. Wittmann, L. Czakó

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Hypertriglyceridemia is reported to cause 1-7% of the cases of acute pancreatitis. Aim: The aim of the present study was to assess the clinical features and management of pancreatitis with hypertriglyceridemia in our tertiary center. Methods: Between 1 January 2007 and 31 December 2009, patients with a diagnosis of hypertriglyceridemia-induced acute pancreatitis were reviewed. Patients with pancreatitis and serum triglyceride levels greater than 11.3 mmol/l (≈1000 mg/dl) were included. Acute pancreatitis with other etiologies was excluded. Results: 26 patients (2 women, 24 men; median age at presentation 42 years; range: 22-70) were diagnosed with hypertriglyceridemia- induced acute pancreatitis; 3 patients had altogether 7 relapses. The total number of cases was 33, which accounted for 4.71% of the total number of acute pancreatitis cases in the examined period. There was a failure in diet in 30.3% and a history of regular alcohol abuse in 57.6% of the cases. A history of diabetes mellitus was present in 38.1%, and gallstones in 9.1% of the cases. Lactescent serum was described on admission in 27.3%. Mean triglyceride level was 47.24 mmol/l (≈4181 mg/dl; 12.4-103.8 mmol/l). Amylase level was elevated to three times the normal in 54.5%, and that of lipase to three times the normal in 58.8%. Necrotizing acute pancreatitis was diagnosed in 7 patients (26.9%), and pseudocyst in 8 patients (30.7%). Administration of insulin, heparin, plasmapheresis and fibrates lowered the triglyceride to 3.71 mmol/l (≈328 mg/dl). Conclusion: The clinical course of acute pancreatitis with hypertriglyceridemia does not differ from acute pancreatitis of other causes. Interestingly, levels of serum pancreatic enzymes may be normal or only minimally elevated. Insulin, heparin, plasmapheresis and fibrates effectively reduce lipid levels and relieve symptoms. A low triglyceride level is necessary to prevent relapses. Orv. Hetil., 2010, 45, 1869-1874.

Original languageHungarian
Pages (from-to)1869-1874
Number of pages6
JournalOrvosi Hetilap
Volume151
Issue number45
DOIs
Publication statusPublished - Nov 1 2010

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Hypertriglyceridemia
Pancreatitis
Triglycerides
Fibric Acids
Plasmapheresis
Heparin
Serum
Acute Necrotizing Pancreatitis
Insulin
Recurrence
Gallstones
Amylases
Lipase
Alcoholism
Diabetes Mellitus
Diet
Lipids
Enzymes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hypertriglyceridaemia okozta akut pancreatitis sajátosságai beteganyagunkban. / Baranyai, Tamás; Terzin, Viktória; Vajda, Ágota; Wittmann, T.; Czakó, L.

In: Orvosi Hetilap, Vol. 151, No. 45, 01.11.2010, p. 1869-1874.

Research output: Contribution to journalArticle

Baranyai, Tamás ; Terzin, Viktória ; Vajda, Ágota ; Wittmann, T. ; Czakó, L. / Hypertriglyceridaemia okozta akut pancreatitis sajátosságai beteganyagunkban. In: Orvosi Hetilap. 2010 ; Vol. 151, No. 45. pp. 1869-1874.
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AB - Hypertriglyceridemia is reported to cause 1-7% of the cases of acute pancreatitis. Aim: The aim of the present study was to assess the clinical features and management of pancreatitis with hypertriglyceridemia in our tertiary center. Methods: Between 1 January 2007 and 31 December 2009, patients with a diagnosis of hypertriglyceridemia-induced acute pancreatitis were reviewed. Patients with pancreatitis and serum triglyceride levels greater than 11.3 mmol/l (≈1000 mg/dl) were included. Acute pancreatitis with other etiologies was excluded. Results: 26 patients (2 women, 24 men; median age at presentation 42 years; range: 22-70) were diagnosed with hypertriglyceridemia- induced acute pancreatitis; 3 patients had altogether 7 relapses. The total number of cases was 33, which accounted for 4.71% of the total number of acute pancreatitis cases in the examined period. There was a failure in diet in 30.3% and a history of regular alcohol abuse in 57.6% of the cases. A history of diabetes mellitus was present in 38.1%, and gallstones in 9.1% of the cases. Lactescent serum was described on admission in 27.3%. Mean triglyceride level was 47.24 mmol/l (≈4181 mg/dl; 12.4-103.8 mmol/l). Amylase level was elevated to three times the normal in 54.5%, and that of lipase to three times the normal in 58.8%. Necrotizing acute pancreatitis was diagnosed in 7 patients (26.9%), and pseudocyst in 8 patients (30.7%). Administration of insulin, heparin, plasmapheresis and fibrates lowered the triglyceride to 3.71 mmol/l (≈328 mg/dl). Conclusion: The clinical course of acute pancreatitis with hypertriglyceridemia does not differ from acute pancreatitis of other causes. Interestingly, levels of serum pancreatic enzymes may be normal or only minimally elevated. Insulin, heparin, plasmapheresis and fibrates effectively reduce lipid levels and relieve symptoms. A low triglyceride level is necessary to prevent relapses. Orv. Hetil., 2010, 45, 1869-1874.

KW - acute pancreatitis

KW - amylase

KW - heparin

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KW - insulin

KW - lipase

KW - plasmapheresis

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