Acute myocardial infarction enhances the portal venous histamine level in dogs

M. Gyöngyösi, J. Kaszaki, A. Wolfárd, L. Mojzes, J. Németh, Z. Jambrik

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective and Design: The aim of our experiments was to determine the plasma histamine level in the portal venous (VP) blood during acute coronary occlusion and reperfusion. Subjects: 27 adult mongrel dogs of either sex were randomized for three groups: sham-operated controls, occlusion group (group O) and reperfusion group (group R). Treatment: The left circumflex coronary artery (LCx) was proximally occluded and the occlusion was maintained during 6 h (group O), or after a 60-min occlusion the LCx was reperfused (group R). The portal vein was cannulated to take blood samples for hormone measurements. Methods: The plasma histamine concentrations were measured with the radioenzymatic method. Results: The VP plasma histamine level was significantly increased 60 min after the LCx occlusion in groups O (99.9 ± 40.2 vs. 252.9 ± 100 pg/ml, mean ± SD) and R (101.2 ± 55.1 vs. 179.8 ± 96 pg/ml), and remained high in group O (240.4 ± 8l pg/ml), while 2 h after LCx reperfusion it had decreased to the basic level. There was no correlation between the hemodynamic parameters and the portal vein plasma histamine levels. Conclusions: Histamine is released into the gastrointestinal tract during acute myocardial ischemia and reperfusion, but the release of the vasoactive drug has no effect on systemic hemodynamics.

Original languageEnglish
Pages (from-to)253-259
Number of pages7
JournalInflammation Research
Volume46
Issue number7
DOIs
Publication statusPublished - 1997

Fingerprint

Histamine
Myocardial Infarction
Dogs
Plasmas
Myocardial Reperfusion
Hemodynamics
Portal Vein
Reperfusion
Blood
Coronary Occlusion
Myocardial Ischemia
Gastrointestinal Tract
Coronary Vessels
Hormones
Control Groups
Pharmaceutical Preparations
Experiments

Keywords

  • Acute coronary occlusion
  • Coronary reperfusion
  • Experimental myocardial infarction
  • Gastrointestinal
  • Histamine

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)
  • Immunology
  • Cell Biology

Cite this

Acute myocardial infarction enhances the portal venous histamine level in dogs. / Gyöngyösi, M.; Kaszaki, J.; Wolfárd, A.; Mojzes, L.; Németh, J.; Jambrik, Z.

In: Inflammation Research, Vol. 46, No. 7, 1997, p. 253-259.

Research output: Contribution to journalArticle

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abstract = "Objective and Design: The aim of our experiments was to determine the plasma histamine level in the portal venous (VP) blood during acute coronary occlusion and reperfusion. Subjects: 27 adult mongrel dogs of either sex were randomized for three groups: sham-operated controls, occlusion group (group O) and reperfusion group (group R). Treatment: The left circumflex coronary artery (LCx) was proximally occluded and the occlusion was maintained during 6 h (group O), or after a 60-min occlusion the LCx was reperfused (group R). The portal vein was cannulated to take blood samples for hormone measurements. Methods: The plasma histamine concentrations were measured with the radioenzymatic method. Results: The VP plasma histamine level was significantly increased 60 min after the LCx occlusion in groups O (99.9 ± 40.2 vs. 252.9 ± 100 pg/ml, mean ± SD) and R (101.2 ± 55.1 vs. 179.8 ± 96 pg/ml), and remained high in group O (240.4 ± 8l pg/ml), while 2 h after LCx reperfusion it had decreased to the basic level. There was no correlation between the hemodynamic parameters and the portal vein plasma histamine levels. Conclusions: Histamine is released into the gastrointestinal tract during acute myocardial ischemia and reperfusion, but the release of the vasoactive drug has no effect on systemic hemodynamics.",
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AU - Gyöngyösi, M.

AU - Kaszaki, J.

AU - Wolfárd, A.

AU - Mojzes, L.

AU - Németh, J.

AU - Jambrik, Z.

PY - 1997

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N2 - Objective and Design: The aim of our experiments was to determine the plasma histamine level in the portal venous (VP) blood during acute coronary occlusion and reperfusion. Subjects: 27 adult mongrel dogs of either sex were randomized for three groups: sham-operated controls, occlusion group (group O) and reperfusion group (group R). Treatment: The left circumflex coronary artery (LCx) was proximally occluded and the occlusion was maintained during 6 h (group O), or after a 60-min occlusion the LCx was reperfused (group R). The portal vein was cannulated to take blood samples for hormone measurements. Methods: The plasma histamine concentrations were measured with the radioenzymatic method. Results: The VP plasma histamine level was significantly increased 60 min after the LCx occlusion in groups O (99.9 ± 40.2 vs. 252.9 ± 100 pg/ml, mean ± SD) and R (101.2 ± 55.1 vs. 179.8 ± 96 pg/ml), and remained high in group O (240.4 ± 8l pg/ml), while 2 h after LCx reperfusion it had decreased to the basic level. There was no correlation between the hemodynamic parameters and the portal vein plasma histamine levels. Conclusions: Histamine is released into the gastrointestinal tract during acute myocardial ischemia and reperfusion, but the release of the vasoactive drug has no effect on systemic hemodynamics.

AB - Objective and Design: The aim of our experiments was to determine the plasma histamine level in the portal venous (VP) blood during acute coronary occlusion and reperfusion. Subjects: 27 adult mongrel dogs of either sex were randomized for three groups: sham-operated controls, occlusion group (group O) and reperfusion group (group R). Treatment: The left circumflex coronary artery (LCx) was proximally occluded and the occlusion was maintained during 6 h (group O), or after a 60-min occlusion the LCx was reperfused (group R). The portal vein was cannulated to take blood samples for hormone measurements. Methods: The plasma histamine concentrations were measured with the radioenzymatic method. Results: The VP plasma histamine level was significantly increased 60 min after the LCx occlusion in groups O (99.9 ± 40.2 vs. 252.9 ± 100 pg/ml, mean ± SD) and R (101.2 ± 55.1 vs. 179.8 ± 96 pg/ml), and remained high in group O (240.4 ± 8l pg/ml), while 2 h after LCx reperfusion it had decreased to the basic level. There was no correlation between the hemodynamic parameters and the portal vein plasma histamine levels. Conclusions: Histamine is released into the gastrointestinal tract during acute myocardial ischemia and reperfusion, but the release of the vasoactive drug has no effect on systemic hemodynamics.

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