Acute liver transplantation in a 41-year-old male patient presenting symptoms of adult-onset Still's disease

Fanni Gelley, Attila Doros, Tamás Micsik, János Fazakas, Imre Fehérvári, Gergely Zádori, Zsófia Müller, András Gelley, Balázs Nemes

Research output: Contribution to journalArticle

Abstract

Adult-onset Still's disease is a rare systemic non-infectious inflammatory disease of unknown aetiology. It is characterized by high spiking fever, sore throat, arthralgia, transient maculopapular rash, hepatosplenomegaly, liver cytolysis, weight loss, leukocytosis, neutrophilia, lymphadenopathy, myopathia and polyserositis. Mild or moderate liver involvement is common but fulminate liver failure is a rare manifestation. We report a 41-year-old male with undiagnosed adult Still's disease who underwent liver transplantation due to acute fulminate liver failure. He died 6 months after the liver transplantation in a septic condition. To date, six patients with adult Still's disease-related liver failure have been reported who required liver transplantation. We emphasize that adult Still's disease should be considered in the differential diagnosis of fulminate liver failure, especially in young adults with fever of unknown aetiology or typical features in the history.

Original languageEnglish
Pages (from-to)9-13
Number of pages5
JournalInterventional Medicine and Applied Science
Volume3
Issue number1
DOIs
Publication statusPublished - Mar 1 2011

Keywords

  • Still's disease
  • adult-onset
  • fever
  • fulminate liver failure
  • liver transplantation
  • unknown aetiology

ASJC Scopus subject areas

  • Medicine(all)

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