Acute hemorrhagic shock decreases airway resistance in anesthetized rat

Sam Bayat, Gergely Albu, Skander Layachi, Flore Portier, Marc Fathi, Ferenc Peták, Walid Habre

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We studied the relation between changes in pulmonary and systemic hemodynamics to those in the airway resistance, respiratory tissue mechanics, and thoracic gas volume (TGV) following acute hemorrhage and blood reinfusion in rats. Forced oscillation technique was used to measure airway resistance (Raw), respiratory tissue damping, and elastance at baseline and after stepwise 1-ml blood withdrawals up to 5 ml total, followed by stepwise reinfusion up to full restoration. Mean systemic (Pam) and pulmonary arterial pressures and suprarenal aortic blood flow were measured at each step. In supplemental animals, plethysmographic TGV, Pam, and respiratory mechanics measurements were performed. Blood volume loss (BVL) led to proportional decreases in Raw (66.5 ± 8.8 vs. 44.8 ± 9.0 cmH 2O·s·l -1 with 5 ml, P <0.001), Pam, and aortic blood flow. In contrast, tissue damping increased significantly (1,070 ± 91 vs. 1,235 ± 105 cmH 2O/l, P = 0.009 with 5 ml BVL), whereas tissue elastance did not change significantly. TGV significantly increased with acute BVL (3.7 ± 0.2 vs. 4.2 ± 0.2 ml, P = 0.01). Stepwise reinfusions produced opposite changes in the above parameters, with Raw reaching a higher value than baseline (P = 0.001) upon full volume restoration. Both adrenalin (P = 0.015) and noradrenalin levels were elevated (P = 0.010) after 5-ml blood withdrawal. Our data suggest that the decreases in Raw following BVL may be attributed to the following: 1) an increased TGV enhancing airway parenchymal tethering forces; and 2) an increase in circulating catecholamines. The apparent beneficial effect of a reduction in Raw in acute hemorrhagic shock is counteracted by an increase in dead space and the appearance of peripheral mechanical heterogeneities due to de-recruitment of the pulmonary vasculature.

Original languageEnglish
Pages (from-to)458-464
Number of pages7
JournalJournal of Applied Physiology
Volume111
Issue number2
DOIs
Publication statusPublished - Aug 2011

Fingerprint

Airway Resistance
Hemorrhagic Shock
Blood Volume
Thorax
Gases
Respiratory Mechanics
Lung
Epinephrine
Catecholamines
Norepinephrine
Arterial Pressure
Hemodynamics
Hemorrhage

Keywords

  • Airway resistance
  • Circulatory shock
  • Forced oscillations
  • Pulmonary circulation
  • Respiratory mechanics

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Acute hemorrhagic shock decreases airway resistance in anesthetized rat. / Bayat, Sam; Albu, Gergely; Layachi, Skander; Portier, Flore; Fathi, Marc; Peták, Ferenc; Habre, Walid.

In: Journal of Applied Physiology, Vol. 111, No. 2, 08.2011, p. 458-464.

Research output: Contribution to journalArticle

Bayat, Sam ; Albu, Gergely ; Layachi, Skander ; Portier, Flore ; Fathi, Marc ; Peták, Ferenc ; Habre, Walid. / Acute hemorrhagic shock decreases airway resistance in anesthetized rat. In: Journal of Applied Physiology. 2011 ; Vol. 111, No. 2. pp. 458-464.
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