Acute and subchronic effects of lead on the central and peripheral nervous systems in rats in combination with alcohol

Research output: Contribution to journalArticle

Abstract

Humans are exposed, either simultaneously or sequentially, to various chemicals, including the neurotoxicants lead and ethanol. The aim of the present work was to investigate the changes in the spontaneous cortical activity (electrocorticogram; ECoG) and in the stimulus-dependent evoked potentials (EPs) recorded from rats pre-treated with alcohol and treated with lead acutely (intraperitoneally) or subchronically (by gavage). The measured parameters were spectral composition of the ECoG, amplitude and the latency of the stimulus-evoked cortical potential, as well as compound action potential amplitude, conduction velocity, and relative and absolute refractory period in a peripheral nerve. With subchronic lead and alcohol treatment, significant increase in the frequency of spontaneous activity and slight decrease in the EP amplitude were seen. In acute administration, EP amplitude increased and conduction velocity of the tail nerve decreased significantly. Our results showed that, in a combined exposure situation which is likely to happen also in humans, the known effects of neurotoxic heavy metals can be more severe.

Original languageEnglish
Pages (from-to)139-144
Number of pages6
JournalEcotoxicology and Environmental Safety
Volume61
Issue number2
DOIs
Publication statusPublished - Jun 2005

Fingerprint

Bioelectric potentials
Peripheral Nervous System
Neurology
nervous system
Evoked Potentials
Rats
alcohol
Alcohols
Central Nervous System
Lead
Heavy Metals
Peripheral Nerves
Action Potentials
Tail
ethanol
Ethanol
Refractory materials
Heavy metals
heavy metal
effect

Keywords

  • Acute exposure
  • Alcohol
  • Combined exposure
  • Electrocorticogram
  • Evoked activity
  • Lead
  • Neurotoxicity
  • Subchronic exposure

ASJC Scopus subject areas

  • Environmental Chemistry
  • Environmental Science(all)

Cite this

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title = "Acute and subchronic effects of lead on the central and peripheral nervous systems in rats in combination with alcohol",
abstract = "Humans are exposed, either simultaneously or sequentially, to various chemicals, including the neurotoxicants lead and ethanol. The aim of the present work was to investigate the changes in the spontaneous cortical activity (electrocorticogram; ECoG) and in the stimulus-dependent evoked potentials (EPs) recorded from rats pre-treated with alcohol and treated with lead acutely (intraperitoneally) or subchronically (by gavage). The measured parameters were spectral composition of the ECoG, amplitude and the latency of the stimulus-evoked cortical potential, as well as compound action potential amplitude, conduction velocity, and relative and absolute refractory period in a peripheral nerve. With subchronic lead and alcohol treatment, significant increase in the frequency of spontaneous activity and slight decrease in the EP amplitude were seen. In acute administration, EP amplitude increased and conduction velocity of the tail nerve decreased significantly. Our results showed that, in a combined exposure situation which is likely to happen also in humans, the known effects of neurotoxic heavy metals can be more severe.",
keywords = "Acute exposure, Alcohol, Combined exposure, Electrocorticogram, Evoked activity, Lead, Neurotoxicity, Subchronic exposure",
author = "L{\'a}szl{\'o} Pecze and A. Papp and L. Instit{\'o}ris and A. Szab{\'o} and L. Nagymajt{\'e}nyi",
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T1 - Acute and subchronic effects of lead on the central and peripheral nervous systems in rats in combination with alcohol

AU - Pecze, László

AU - Papp, A.

AU - Institóris, L.

AU - Szabó, A.

AU - Nagymajtényi, L.

PY - 2005/6

Y1 - 2005/6

N2 - Humans are exposed, either simultaneously or sequentially, to various chemicals, including the neurotoxicants lead and ethanol. The aim of the present work was to investigate the changes in the spontaneous cortical activity (electrocorticogram; ECoG) and in the stimulus-dependent evoked potentials (EPs) recorded from rats pre-treated with alcohol and treated with lead acutely (intraperitoneally) or subchronically (by gavage). The measured parameters were spectral composition of the ECoG, amplitude and the latency of the stimulus-evoked cortical potential, as well as compound action potential amplitude, conduction velocity, and relative and absolute refractory period in a peripheral nerve. With subchronic lead and alcohol treatment, significant increase in the frequency of spontaneous activity and slight decrease in the EP amplitude were seen. In acute administration, EP amplitude increased and conduction velocity of the tail nerve decreased significantly. Our results showed that, in a combined exposure situation which is likely to happen also in humans, the known effects of neurotoxic heavy metals can be more severe.

AB - Humans are exposed, either simultaneously or sequentially, to various chemicals, including the neurotoxicants lead and ethanol. The aim of the present work was to investigate the changes in the spontaneous cortical activity (electrocorticogram; ECoG) and in the stimulus-dependent evoked potentials (EPs) recorded from rats pre-treated with alcohol and treated with lead acutely (intraperitoneally) or subchronically (by gavage). The measured parameters were spectral composition of the ECoG, amplitude and the latency of the stimulus-evoked cortical potential, as well as compound action potential amplitude, conduction velocity, and relative and absolute refractory period in a peripheral nerve. With subchronic lead and alcohol treatment, significant increase in the frequency of spontaneous activity and slight decrease in the EP amplitude were seen. In acute administration, EP amplitude increased and conduction velocity of the tail nerve decreased significantly. Our results showed that, in a combined exposure situation which is likely to happen also in humans, the known effects of neurotoxic heavy metals can be more severe.

KW - Acute exposure

KW - Alcohol

KW - Combined exposure

KW - Electrocorticogram

KW - Evoked activity

KW - Lead

KW - Neurotoxicity

KW - Subchronic exposure

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