Acute and long-term effects of a single dose of MDMA on aggression in Dark Agouti rats

Eszter Kirilly, Anita Benko, Linda Ferrington, Romeo D. Ando, Paul A T Kelly, G. Bagdy

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

MDMA causes selective depletion of serotonergic terminals in experimental animals and the consequent decrease in synaptic 5-HT may, inter alia, increase impulsivity. To study the effects of MDMA upon brain function, the behaviour of male Dark Agouti rats exposed to MDMA (15 mg/kg i.p.), two 5-HT1B agonists (CGS-12066A and CP-94,253, both 5 mg/kg i.p.) or saline were investigated in the resident-intruder test. Studies were performed in drug-naive rats and also in rats exposed to MDMA (15 mg/kg i.p.) 21 d earlier. In parallel experiments the functional neuroanatomy of MDMA effects were assessed using 2-deoxyglucose imaging of local cerebral metabolic rate of glucose utilization (LCMRGlu) and neurotoxicity was assessed by measuring [ 3H]paroxetine binding. There was no significant difference in aggressive behaviour (biting, boxing, wrestling and their latencies) between drug-naive rats and rats previously exposed to MDMA 21 d earlier, despite reduced social behaviour, decreased LCMRGlu in several brain areas involved in aggression, and reductions in paroxetine binding by 30-60% in the forebrain. CGS-12066A, CP-94,253 and acute MDMA produced marked decreases in aggressive behaviours, especially in biting, boxing and kicking found in drug-naive rats. In animals previously exposed to the drug, acute anti-aggressive effects of MDMA were, in general, preserved as were MDMA-induced increases in LCMRGlu. Our studies provide evidence that in the resident-intruder test, where social isolation is a requirement, aggressive behaviour and acute anti-aggressive effects of MDMA and 5-HT1B receptor agonists remain intact 3 wk after a single dose of the drug despite significant damage to the serotonergic system.

Original languageEnglish
Pages (from-to)63-76
Number of pages14
JournalInternational Journal of Neuropsychopharmacology
Volume9
Issue number1
DOIs
Publication statusPublished - Feb 2006

Fingerprint

N-Methyl-3,4-methylenedioxyamphetamine
Aggression
Boxing
Serotonin 5-HT1 Receptor Agonists
Paroxetine
Pharmaceutical Preparations
Glucose
Wrestling
Dasyproctidae
Receptor, Serotonin, 5-HT1B
Neuroanatomy
Social Isolation
Impulsive Behavior
Social Behavior
Deoxyglucose
Brain
Prosencephalon
Serotonin

Keywords

  • 5-HT
  • Aggression
  • Ecstasy
  • Local cerebral metabolic rate of glucose utilization
  • Serotonin transporter

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Acute and long-term effects of a single dose of MDMA on aggression in Dark Agouti rats. / Kirilly, Eszter; Benko, Anita; Ferrington, Linda; Ando, Romeo D.; Kelly, Paul A T; Bagdy, G.

In: International Journal of Neuropsychopharmacology, Vol. 9, No. 1, 02.2006, p. 63-76.

Research output: Contribution to journalArticle

Kirilly, Eszter ; Benko, Anita ; Ferrington, Linda ; Ando, Romeo D. ; Kelly, Paul A T ; Bagdy, G. / Acute and long-term effects of a single dose of MDMA on aggression in Dark Agouti rats. In: International Journal of Neuropsychopharmacology. 2006 ; Vol. 9, No. 1. pp. 63-76.
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