Abstract
Systemic injections of 4-aminopyridine precipitate epileptiform generalized seizures characterized mainly by shivering of the body, tail movements and tonic-clonic convulsions in rats and mice. However, only few details are known as concerns which brain regions are possibly affected and stimulated by the compound. The aim of the present study was to investigate the changes in regional cerebral blood flow in mice by using the lipophilic compound technetium-99m-hexamethyl-propyleneamineoxime (99mTc-HMPAO). Whilst the uptake of 99mTc-HMPAO was increased significantly in the neocortex and thalamus following the induction of acute 4-aminopyridine seizures, no such changes were observed in the allocortex of the mice. The increases in uptake in the neocortex and thalamus were completely prevented by carbamazepine (which abolished the symptoms of the seizure, too). The primary involvement of the neocortex and thalamus points to the importance of thalamocortical circuits in the precipitation and maintenance of experimental 4-aminopyridine convulsions.
| Original language | English |
|---|---|
| Pages (from-to) | 43-52 |
| Number of pages | 10 |
| Journal | Acta Physiologica Hungarica |
| Volume | 87 |
| Issue number | 1 |
| Publication status | Published - 2000 |
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Keywords
- Tc-HMPAO
- Autoradiography
- Cerebral blood flow
- Mice
- Seizure
ASJC Scopus subject areas
- Physiology
Cite this
Acute 4-aminopyridine seizures increase the regional cerebral blood flow in the thalamus and neocortex, but not in the entire allocortex of the mouse brain. / Mihály, A.; Shihab-Eldeen, A.; Owunwanne, A.; Gopinath, S.; Ayesha, A.; Mathew, M.
In: Acta Physiologica Hungarica, Vol. 87, No. 1, 2000, p. 43-52.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Acute 4-aminopyridine seizures increase the regional cerebral blood flow in the thalamus and neocortex, but not in the entire allocortex of the mouse brain
AU - Mihály, A.
AU - Shihab-Eldeen, A.
AU - Owunwanne, A.
AU - Gopinath, S.
AU - Ayesha, A.
AU - Mathew, M.
PY - 2000
Y1 - 2000
N2 - Systemic injections of 4-aminopyridine precipitate epileptiform generalized seizures characterized mainly by shivering of the body, tail movements and tonic-clonic convulsions in rats and mice. However, only few details are known as concerns which brain regions are possibly affected and stimulated by the compound. The aim of the present study was to investigate the changes in regional cerebral blood flow in mice by using the lipophilic compound technetium-99m-hexamethyl-propyleneamineoxime (99mTc-HMPAO). Whilst the uptake of 99mTc-HMPAO was increased significantly in the neocortex and thalamus following the induction of acute 4-aminopyridine seizures, no such changes were observed in the allocortex of the mice. The increases in uptake in the neocortex and thalamus were completely prevented by carbamazepine (which abolished the symptoms of the seizure, too). The primary involvement of the neocortex and thalamus points to the importance of thalamocortical circuits in the precipitation and maintenance of experimental 4-aminopyridine convulsions.
AB - Systemic injections of 4-aminopyridine precipitate epileptiform generalized seizures characterized mainly by shivering of the body, tail movements and tonic-clonic convulsions in rats and mice. However, only few details are known as concerns which brain regions are possibly affected and stimulated by the compound. The aim of the present study was to investigate the changes in regional cerebral blood flow in mice by using the lipophilic compound technetium-99m-hexamethyl-propyleneamineoxime (99mTc-HMPAO). Whilst the uptake of 99mTc-HMPAO was increased significantly in the neocortex and thalamus following the induction of acute 4-aminopyridine seizures, no such changes were observed in the allocortex of the mice. The increases in uptake in the neocortex and thalamus were completely prevented by carbamazepine (which abolished the symptoms of the seizure, too). The primary involvement of the neocortex and thalamus points to the importance of thalamocortical circuits in the precipitation and maintenance of experimental 4-aminopyridine convulsions.
KW - Tc-HMPAO
KW - Autoradiography
KW - Cerebral blood flow
KW - Mice
KW - Seizure
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UR - http://www.scopus.com/inward/citedby.url?scp=0343389546&partnerID=8YFLogxK
M3 - Article
C2 - 11032047
AN - SCOPUS:0343389546
VL - 87
SP - 43
EP - 52
JO - Physiology International
JF - Physiology International
SN - 2498-602X
IS - 1
ER -