Active disease and residual damage in treated Wegener's granulomatosis: An observational study using pulmonary high-resolution computed tomography

A. Komócsi, Michael Reuter, Martin Heller, Henriette Muraközi, Wolfgang L. Gross, Armin Schnabel

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The purpose of this study was to determine to what extent high-resolution computed tomography (HRCT) of the lungs can distinguish active inflammatory disease from inactive cicatricial disease in patients treated for Wegener's granulomatosis (WG). Twenty-eight WG patients with active pulmonary disease underwent a first HRCT examination immediately before standard immunosuppressive treatment and a second examination after clinical remission had been achieved. Lesions remaining after treatment were categorized as residual damage and were compared with findings during active disease to see by what features active and cicatricial disease can be distinguished. During active disease 17 patients had nodules/masses, 12 had ground-glass opacities, 6 had septal lines and 6 had non-septal lines. After treatment, ground-glass opacities had resolved completely. Nodules/masses had resolved in 8 patients and had diminished in 7 patients. Residual nodules were distinguished from nodules/masses in active disease by lack of cavitation and a diameter of mostly

Original languageEnglish
Pages (from-to)36-42
Number of pages7
JournalEuropean Radiology
Volume13
Issue number1
Publication statusPublished - Jan 1 2003

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Granulomatosis with Polyangiitis
Observational Studies
Tomography
Lung
Glass
Immunosuppressive Agents
Lung Diseases
Therapeutics

Keywords

  • Computed tomography
  • Granuloma
  • Immunosuppression
  • Lung
  • Vasculitis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Active disease and residual damage in treated Wegener's granulomatosis : An observational study using pulmonary high-resolution computed tomography. / Komócsi, A.; Reuter, Michael; Heller, Martin; Muraközi, Henriette; Gross, Wolfgang L.; Schnabel, Armin.

In: European Radiology, Vol. 13, No. 1, 01.01.2003, p. 36-42.

Research output: Contribution to journalArticle

Komócsi, A. ; Reuter, Michael ; Heller, Martin ; Muraközi, Henriette ; Gross, Wolfgang L. ; Schnabel, Armin. / Active disease and residual damage in treated Wegener's granulomatosis : An observational study using pulmonary high-resolution computed tomography. In: European Radiology. 2003 ; Vol. 13, No. 1. pp. 36-42.
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