Active conformation in amine-thiourea bifunctional organocatalysis preformed by catalyst aggregation

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Self-activation: Takemoto's catalyst gains access to its active conformation by equilibrating between its hydrogen-bonded intra- and intermolecular interactions in apolar aprotic solvents. By destabilization of the inactive monomeric conformations, the extended anti-anti thiourea conformation is preformed in the assembly. On leaving the assembly, this transient conformation has a structural preference to become a catalytically active monomeric species that has the potency for dual activation (see scheme).

Original languageEnglish
Pages (from-to)1918-1922
Number of pages5
JournalChemistry - A European Journal
Volume18
Issue number7
DOIs
Publication statusPublished - Feb 13 2012

Fingerprint

Thiourea
Thioureas
Amines
Conformations
Agglomeration
Catalysts
Chemical activation
Hydrogen

Keywords

  • bifunctional catalysts
  • molecular recognition
  • organocatalysis
  • self-association

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Active conformation in amine-thiourea bifunctional organocatalysis preformed by catalyst aggregation. / Tárkányi, G.; Király, P.; Soós, T.; Varga, Szilárd.

In: Chemistry - A European Journal, Vol. 18, No. 7, 13.02.2012, p. 1918-1922.

Research output: Contribution to journalArticle

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