Activation of TRPV3 Regulates Inflammatory Actions of Human Epidermal Keratinocytes

Attila Gábor Szöllősi, Nikolett Vasas, Ágnes Angyal, Kornél Kistamás, Péter Pál Nánási, Johanna Mihály, Gabriella Béke, Erika Herczeg-Lisztes, Andrea Szegedi, Naoki Kawada, Takashi Yanagida, Takahiro Mori, Lajos Kemény, Tamás Bíró

Research output: Contribution to journalArticle

19 Citations (Scopus)


Transient receptor potential (TRP) ion channels were first characterized on neurons, where they are classically implicated in sensory functions; however, research in recent decades has shown that many of these channels are also expressed on nonneuronal cell types. Emerging findings have highlighted the role of TRP channels in the skin, where they have been shown to be important in numerous cutaneous functions. Of particular interest is TRPV3, which was first described on keratinocytes. Its functional importance was supported when its gain-of-function mutation was linked to Olmsted syndrome, which is characterized by palmoplantar keratoderma, periorifacial hyperkeratosis, diffuse hypotrichosis and alopecia, and itch. Despite these exciting results, we have no information about the role and functionality of TRPV3 on keratinocytes at the cellular level. In this study, we identified TRPV3 expression both on human skin and cultured epidermal keratinocytes. TRPV3 stimulation was found to function as a Ca 2+ -permeable ion channel that suppresses proliferation of epidermal keratinocytes and induces cell death. Stimulation of the channel also triggers a strong proinflammatory response via the NF-κB pathway. Collectively, our data show that TRPV3 is functionally expressed on human epidermal keratinocytes and that it plays a role in cutaneous inflammatory processes.

Original languageEnglish
Pages (from-to)365-374
Number of pages10
JournalJournal of Investigative Dermatology
Issue number2
Publication statusPublished - Feb 2018

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

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    Szöllősi, A. G., Vasas, N., Angyal, Á., Kistamás, K., Nánási, P. P., Mihály, J., Béke, G., Herczeg-Lisztes, E., Szegedi, A., Kawada, N., Yanagida, T., Mori, T., Kemény, L., & Bíró, T. (2018). Activation of TRPV3 Regulates Inflammatory Actions of Human Epidermal Keratinocytes. Journal of Investigative Dermatology, 138(2), 365-374.