Activation of oxidative stress response by hydroxyl substituted chalcones and cyclic chalcone analogues in mitochondria

J. Guzy, J. Vašková-Kubálková, Z. Rozmer, K. Fodor, M. Mareková, M. Poškrobová, P. Perjési

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

We investigated the effect of hydroxyl substituted chalcone (1a) and some chalcone analogues (1b-d) on isolated rat liver mitochondria to gain new insights into the cytotoxic mechanism of these compounds. We observed an inhibitory effect on phosphorylation and the partial uncoupling of compounds 1a and 1d. Increased radical generation and possible covalent interaction of the compounds with cellular thiols resulted in glutathione (GSH) depletion and modulation of the investigated mitochondrial activities. Disruption of interconnected mechanisms as electron transport chain and energetic metabolism, ROS production and insufficiency of antioxidant defensive system could lead to induction of cell death.

Original languageEnglish
Pages (from-to)567-570
Number of pages4
JournalFEBS Letters
Volume584
Issue number3
DOIs
Publication statusPublished - Feb 5 2010

Fingerprint

Chalcones
Chalcone
Mitochondria
Oxidative stress
Hydroxyl Radical
Oxidative Stress
Chemical activation
Phosphorylation
Liver Mitochondrion
Cell death
Electron Transport
Sulfhydryl Compounds
Metabolism
Liver
Glutathione
Rats
Cell Death
Antioxidants
Modulation

Keywords

  • Cyclic chalcone analogue
  • Glutathione
  • Hydroxyl radical
  • Mitochondria
  • Oxidative stress
  • Respiration

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Genetics
  • Molecular Biology
  • Structural Biology

Cite this

Activation of oxidative stress response by hydroxyl substituted chalcones and cyclic chalcone analogues in mitochondria. / Guzy, J.; Vašková-Kubálková, J.; Rozmer, Z.; Fodor, K.; Mareková, M.; Poškrobová, M.; Perjési, P.

In: FEBS Letters, Vol. 584, No. 3, 05.02.2010, p. 567-570.

Research output: Contribution to journalArticle

Guzy, J, Vašková-Kubálková, J, Rozmer, Z, Fodor, K, Mareková, M, Poškrobová, M & Perjési, P 2010, 'Activation of oxidative stress response by hydroxyl substituted chalcones and cyclic chalcone analogues in mitochondria', FEBS Letters, vol. 584, no. 3, pp. 567-570. https://doi.org/10.1016/j.febslet.2009.11.098
Guzy J, Vašková-Kubálková J, Rozmer Z, Fodor K, Mareková M, Poškrobová M et al. Activation of oxidative stress response by hydroxyl substituted chalcones and cyclic chalcone analogues in mitochondria. FEBS Letters. 2010 Feb 5;584(3):567-570. https://doi.org/10.1016/j.febslet.2009.11.098
Guzy, J. ; Vašková-Kubálková, J. ; Rozmer, Z. ; Fodor, K. ; Mareková, M. ; Poškrobová, M. ; Perjési, P. / Activation of oxidative stress response by hydroxyl substituted chalcones and cyclic chalcone analogues in mitochondria. In: FEBS Letters. 2010 ; Vol. 584, No. 3. pp. 567-570.
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