Activation of herpes specific antigens and infectious virus in a hamster cell line transformed by HSV-2

L. Váczi, I. Boldogh, Eva Gönczöl

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

An established cell line transformed by herpes simplex virus type 2 and derived from hamster tumors contained herpesvirus specific intraeellular and surface antigens in about 2-5 per cent of cells but did not produce infectious virus. Arginine deprivation resulted in induction of virus specific intracellular and surface antigens in 70-75 and about 40 per cent of cells, respectively, while no infectious virus was induced. After treatment of the cultures with IUDR 70-75 per cent of the cells showed virus specific intracellular fluorescence and 45-50 per cent exhibited cell membrane fluorescence and infectious virus could be detected. The induction by IUDR could be inhibited by simultaneous treatment of cultures with cytosine arabinoside (ara-C).

Original languageEnglish
Pages (from-to)62-69
Number of pages8
JournalArchiv für die gesamte Virusforschung
Volume44
Issue number1
DOIs
Publication statusPublished - Mar 1 1974

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Genetics

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