Activation energies of fragmentations of disaccharides by tandem mass spectrometry

Ákos Kuki, Lajos Nagy, Katalin E. Szabó, Borbála Antal, Miklós Zsuga, Sándor Kéki

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2 Citations (Scopus)

Abstract

A simple multiple collision model for collision induced dissociation (CID) in quadrupole was applied for the estimation of the activation energy (E o) of the fragmentation processes for lithiated and trifluoroacetated disaccharides, such as maltose, cellobiose, isomaltose, gentiobiose, and trehalose. The internal energy-dependent rate constants k(Eint) were calculated using the Rice-Ramsperger-Kassel-Marcus (RRKM) or the Rice-Ramsperger-Kassel (RRK) theory. The Eo values were estimated by fitting the calculated survival yield (SY) curves to the experimental ones. The calculated Eo values of the fragmentation processes for lithiated disaccharides were in the range of 1.4-1.7 eV, and were found to increase in the order trehalose < maltose < isomaltose < cellobiose < gentiobiose. [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)439-443
Number of pages5
JournalJournal of the American Society for Mass Spectrometry
Volume25
Issue number3
DOIs
Publication statusPublished - Mar 1 2014

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Keywords

  • Collision-induced dissociation
  • Disaccharides
  • Multiple collisions
  • RRK and RRKM model
  • Tandem mass spectrometry

ASJC Scopus subject areas

  • Structural Biology
  • Spectroscopy

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