Action of posterior pituitary neuropeptides on the nigrostriatal dopaminergic system

Horst Schulz, G. Kovács, G. Telegdy

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The effect of vasopressin, oxytocin and the C-terminal tripeptide of oxytocin, prolyl-leucyl-glycinamide (PLG), were tested on rotational behavior, following unilateral 6-OHDA-induced lesion of the dopaminergic cell bodies in the substantia nigra. Intraventricular injection of lysin8-vasopressin, oxytocin or PLG caused ipsilateral (towards the lesioned side) rotation, as did peripheral administration of amphetamine. Direct local microinjection of the peptides into the substantia nigra on the intact side was without effect. The data suggest that posterior pituitary neuropeptides (vasopressin and oxytocin) caused presynaptic activation of the nigrostriatal dopaminergic terminals.

Original languageEnglish
Pages (from-to)185-190
Number of pages6
JournalEuropean Journal of Pharmacology
Volume57
Issue number2-3
DOIs
Publication statusPublished - Aug 1 1979

Fingerprint

Oxytocin
Neuropeptides
MSH Release-Inhibiting Hormone
Vasopressins
Substantia Nigra
Intraventricular Injections
Oxidopamine
Microinjections
Amphetamine
Peptides

Keywords

  • Oxytocin
  • PLG
  • Rotational behavior
  • Vasopressin

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Action of posterior pituitary neuropeptides on the nigrostriatal dopaminergic system. / Schulz, Horst; Kovács, G.; Telegdy, G.

In: European Journal of Pharmacology, Vol. 57, No. 2-3, 01.08.1979, p. 185-190.

Research output: Contribution to journalArticle

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