Action of pancreatic polypeptide on exocrine pancreas and on release of cholecystokinin and secretin

J. Lonovics, S. Guzman, P. G. Devitt, K. E. Hejtmancik, R. L. Suddith, P. L. Rayford, J. C. Thompson

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We have studied the effect of exogenous porcine pancreatic polypeptide (PP;0.8 and 2.1 μg/kg.h, iv) on endogenously stimulated pancreatic exocrine secretion in five pancreatic-fistula dogs. Plasma levels of cholecystokinin (CCK), secretin, and PP were measured in addition to pancreatic secretion of water, bicarbonate, and protein. Intraduodenal infusions of acid and a mixture of phenylalanine and tryptophan were used to stimulate hormone release. PP caused a dose-dependent inhibition of endogenously stimulated pancreatic secretion, whereas the release of CCK and secretin was not affected. Duodenal acidification and intraduodenal infusion of phenylalanine and tryptophan caused a significant release of PP. This study shows that: 1) PP suppresses pancreatic secretion by means of a mechanism that is probably direct; this effect is not mediated through inhibition of release of CCK or secretin, and 2) phenylalanine and tryptophan, both strong stimulants of CCK release, cause a substantial rise in PP in peripheral blood. The mechanism of PP release may involve CCK (in previous studies, we have shown a rise in circulating PP levels after iv CCK infusion).

Original languageEnglish
Pages (from-to)1925-1930
Number of pages6
JournalEndocrinology
Volume108
Issue number5
Publication statusPublished - 1981

Fingerprint

Pancreatic Polypeptide
Exocrine Pancreas
Secretin
Cholecystokinin
Phenylalanine
Tryptophan
Pancreatic Fistula
Bicarbonates
Swine
Hormones
Dogs
Acids
Water
Proteins

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Lonovics, J., Guzman, S., Devitt, P. G., Hejtmancik, K. E., Suddith, R. L., Rayford, P. L., & Thompson, J. C. (1981). Action of pancreatic polypeptide on exocrine pancreas and on release of cholecystokinin and secretin. Endocrinology, 108(5), 1925-1930.

Action of pancreatic polypeptide on exocrine pancreas and on release of cholecystokinin and secretin. / Lonovics, J.; Guzman, S.; Devitt, P. G.; Hejtmancik, K. E.; Suddith, R. L.; Rayford, P. L.; Thompson, J. C.

In: Endocrinology, Vol. 108, No. 5, 1981, p. 1925-1930.

Research output: Contribution to journalArticle

Lonovics, J, Guzman, S, Devitt, PG, Hejtmancik, KE, Suddith, RL, Rayford, PL & Thompson, JC 1981, 'Action of pancreatic polypeptide on exocrine pancreas and on release of cholecystokinin and secretin', Endocrinology, vol. 108, no. 5, pp. 1925-1930.
Lonovics J, Guzman S, Devitt PG, Hejtmancik KE, Suddith RL, Rayford PL et al. Action of pancreatic polypeptide on exocrine pancreas and on release of cholecystokinin and secretin. Endocrinology. 1981;108(5):1925-1930.
Lonovics, J. ; Guzman, S. ; Devitt, P. G. ; Hejtmancik, K. E. ; Suddith, R. L. ; Rayford, P. L. ; Thompson, J. C. / Action of pancreatic polypeptide on exocrine pancreas and on release of cholecystokinin and secretin. In: Endocrinology. 1981 ; Vol. 108, No. 5. pp. 1925-1930.
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