Action of histamine on PHA chemiluminescence response of blood mononuclear cells in autoimmune patients

K. Meretey, U. Bohm, A. Falus

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Peripheral blood mononuclar cells (PBMs) of patients suffering from autoimmune diseases showed significantly lower chemiluminescence response to PHA than the controls. High doses of histamine (10-5 M) inhibited the chemiluminescence while low doses caused a mild enhancement in all groups of patients. The preformed histamine content of the PMBs was not significantly higher in the patients than in the controls. Individually, a reverse correlation was found between the activity of the disease and the sensitivity of the cells to histamine. In very active cases, virtually no inhibition by histamine was found.

Original languageEnglish
Pages (from-to)254-257
Number of pages4
JournalAgents and Actions
Volume18
Issue number1-2
DOIs
Publication statusPublished - Apr 1986

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Chemiluminescence
Luminescence
Histamine
Blood Cells
Blood
Autoimmune Diseases

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)

Cite this

Action of histamine on PHA chemiluminescence response of blood mononuclear cells in autoimmune patients. / Meretey, K.; Bohm, U.; Falus, A.

In: Agents and Actions, Vol. 18, No. 1-2, 04.1986, p. 254-257.

Research output: Contribution to journalArticle

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