Action of cathepsin D on human β-lipotropin: A possible source of human 'β-melanotropin'

E. Barat, A. Patthy, L. Graf

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Highly purified calf brain cathepsin D (EC 3.4.23.5) selectively splits the Leu77-Phe78 and Ala38-Ala37 peptide bonds of human β-lipotropin. It is suggested that the formation of human 'β-melanotropin' from γ-lipotropin, and that of γ-endophine from β-endorphin, is due to the action of cathepsin D during isolation procedures.

Original languageEnglish
Pages (from-to)6120-6123
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume76
Issue number12
DOIs
Publication statusPublished - 1979

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Action of cathepsin D on human β-lipotropin: A possible source of human 'β-melanotropin''. Together they form a unique fingerprint.

  • Cite this