Highly purified calf brain cathepsin D (EC 18.104.22.168) selectively splits the Leu77-Phe78 and Ala38-Ala37 peptide bonds of human β-lipotropin. It is suggested that the formation of human 'β-melanotropin' from γ-lipotropin, and that of γ-endophine from β-endorphin, is due to the action of cathepsin D during isolation procedures.
|Number of pages||4|
|Journal||Proceedings of the National Academy of Sciences of the United States of America|
|Publication status||Published - 1979|
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