Actin, actin-binding proteins, and actin-related proteins in the nucleus

Ildikó Kristó, Izabella Bajusz, Csaba Bajusz, Péter Borkúti, P. Vilmos

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Extensive research in the past decade has significantly broadened our view about the role actin plays in the life of the cell and added novel aspects to actin research. One of these new aspects is the discovery of the existence of nuclear actin which became evident only recently. Nuclear activities including transcriptional activation in the case of all three RNA polymerases, editing and nuclear export of mRNAs, and chromatin remodeling all depend on actin. It also became clear that there is a fine-tuned equilibrium between cytoplasmic and nuclear actin pools and that this balance is ensured by an export–import system dedicated to actin. After over half a century of research on conventional actin and its organizing partners in the cytoplasm, it was also an unexpected finding that the nucleus contains more than 30 actin-binding proteins and new classes of actin-related proteins which are not able to form filaments but had evolved nuclear-specific functions. The actin-binding and actin-related proteins in the nucleus have been linked to RNA transcription and processing, nuclear transport, and chromatin remodeling. In this paper, we attempt to provide an overview of the wide range of information that is now available about actin, actin-binding, and actin-related proteins in the nucleus.

Original languageEnglish
Pages (from-to)373-388
Number of pages16
JournalHistochemistry and Cell Biology
Volume145
Issue number4
DOIs
Publication statusPublished - Apr 1 2016

Fingerprint

Microfilament Proteins
Actins
Proteins
Chromatin Assembly and Disassembly
Cell Nucleus Active Transport
Research
RNA Editing
DNA-Directed RNA Polymerases
Transcriptional Activation
Cytoplasm

Keywords

  • ABP
  • Actin-binding protein
  • Actin-related protein
  • ARP
  • Nuclear actin
  • Nucleus

ASJC Scopus subject areas

  • Cell Biology
  • Histology
  • Medical Laboratory Technology
  • Molecular Biology

Cite this

Actin, actin-binding proteins, and actin-related proteins in the nucleus. / Kristó, Ildikó; Bajusz, Izabella; Bajusz, Csaba; Borkúti, Péter; Vilmos, P.

In: Histochemistry and Cell Biology, Vol. 145, No. 4, 01.04.2016, p. 373-388.

Research output: Contribution to journalArticle

Kristó, Ildikó ; Bajusz, Izabella ; Bajusz, Csaba ; Borkúti, Péter ; Vilmos, P. / Actin, actin-binding proteins, and actin-related proteins in the nucleus. In: Histochemistry and Cell Biology. 2016 ; Vol. 145, No. 4. pp. 373-388.
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