ACTH release after tuberal electrical stimulation in rats with various cuts around the medial basal hypothalamus

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

After the combined treatment with dexamethasone, morphine and pentobarbitone, the electrical stimulation in the rat tuber cinereum induces a rise in plasma corticosterone (CS) level, probably by direct stimulation of the corticoliberin-producing neural elements and the consecutive ACTH release. We have attempted to locate these corticoliberin-containing neural elements by electrical stimulation in rats with various surgical cuts (deafferentations) around the medial basal hypothalamus (MBH). Seven to eight days after the complete circumsection of the MBH, the electrical stimulation of the isolated region did not affect plasma CS level. Also, the electrical excitation proved to be ineffective after antero-lateral or only lateral medial that interrupted the fibers running through the lateral region of the retrochiasmatic area. In contrast, a rise in CS level followed electrical stimulation of rats with anterolateral transections, provided the basal part of the lateral retrochiasmatic area stayed intact. We suggest that fibers traversing the basal region of the lateral retrochiasmatic area have a major role in the release of corticoliberin from the median eminence (ME)

Original languageEnglish
Pages (from-to)109-118
Number of pages10
JournalNeuroendocrinology
Volume27
Issue number3-4
DOIs
Publication statusPublished - Jan 1 1978

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'ACTH release after tuberal electrical stimulation in rats with various cuts around the medial basal hypothalamus'. Together they form a unique fingerprint.

  • Cite this