ACTH- and Cortisol-Associated Neutrophil Modulation in Coronary Artery Disease Patients Undergoing Stent Implantation

Margit Keresztes, Tamás Horváth, Imre Ocsovszki, Imre Földesi, Gyöngyi Serfozo, Krisztina Boda, Imre Ungi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background:Psychosocial stress and activation of neutrophil granulocytes are increasingly recognized as major risk factors of coronary artery disease (CAD), but the possible relationship of these two factors in CAD patients is largely unexplored. Activation of neutrophils was reported to be associated with stenting; however, the issue of neutrophil state in connection with percutaneous coronary intervention (PCI) is incompletely understood from the aspect of stress and its hypothalamic-pituitary-adrenal axis (HPA) background. Thus, we aimed to study cortisol- and ACTH-associated changes in granulocyte activation in patients undergoing PCI.Methodology/Principal Findings:Blood samples of 21 stable angina pectoris (SAP) and 20 acute coronary syndrome (ACS) patients were collected directly before (pre-PCI), after (post-PCI) and on the following day of PCI (1d-PCI). Granulocyte surface L-selectin, CD15 and (neutrophil-specific) lactoferrin were analysed by flow cytometry. Plasma cortisol, ACTH, and lactoferrin, IL-6 were also assayed. In both groups, pre- and post-PCI ratios of lactoferrin-bearing neutrophils were relatively high, these percentages decreased substantially next day; similarly, 1d-PCI plasma lactoferrin was about half of the post-PCI value (all p≤0.0001). Post-PCI ACTH was reduced markedly next day, especially in ACS group (SAP: p

Original languageEnglish
Article numbere71902
JournalPLoS One
Volume8
Issue number8
DOIs
Publication statusPublished - Aug 14 2013

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Lactoferrin
Stents
corticotropin
Percutaneous Coronary Intervention
Ion implantation
Adrenocorticotropic Hormone
lactoferrin
cortisol
Hydrocortisone
neutrophils
Coronary Artery Disease
Neutrophils
Modulation
granulocytes
Chemical activation
Bearings (structural)
Plasmas
L-Selectin
Granulocytes
Flow cytometry

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

ACTH- and Cortisol-Associated Neutrophil Modulation in Coronary Artery Disease Patients Undergoing Stent Implantation. / Keresztes, Margit; Horváth, Tamás; Ocsovszki, Imre; Földesi, Imre; Serfozo, Gyöngyi; Boda, Krisztina; Ungi, Imre.

In: PLoS One, Vol. 8, No. 8, e71902, 14.08.2013.

Research output: Contribution to journalArticle

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