Acquired C1-esterase inhibitor deficiency and recurrent herpes infection in a patient with chronic lymphocytic leukemia.

D. Minh, E. Czink, G. Füst, S. R. Hollán

Research output: Contribution to journalArticle

Abstract

Profound hypocomplementemia was observed in a patient with chronic lymphocytic leukemia. On the basis of the results of complement measurements performed in nine serum samples taken in a period of 6 mo it was demonstrated that the patient had an acquired form of C1-esterase inhibitor deficiency: marked reduction of CH50, C1, C4, and C1-esterase inhibitor levels with normal alternative pathway, C3, and factor B activities were found. The patient had no typical attacks of angioneurotic edema; however, angioedema-like facial swelling was observed on several occasions in connection with recurrent severe herpes simplex eruptions. The possible association of the marked and long-lasting hypocomplementemia with the clinical course of the herpes infection is discussed.

Original languageEnglish
Pages (from-to)68-71
Number of pages4
JournalDiagnostic immunology
Volume1
Issue number2
Publication statusPublished - Dec 1 1983

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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