Acetylcholine-releasing effect of primycin, a highly active antibiotic

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The effect of primycin, an antibiotic known to inhibit potassium conductance, was studied on acetylcholine (ACh) release from the nerve terminals of the Auerbach plexus and cortical slice of the rat. Primycin enhanced the resting release of ACh; however, it failed to affect the amount of ACh released by a single shock. It has no effect on Na+K+-activated ATPase. Its effect on ACh release was prevented by tetrodotoxin and by Ca removal. It is concluded that its effect on potassium conductance might account for its ACh-releasing effect: it produces depolarization and spontaneous firing.

Original languageEnglish
Pages (from-to)268-274
Number of pages7
JournalPharmacology
Volume20
Issue number5
Publication statusPublished - 1980

Fingerprint

Acetylcholine
Anti-Bacterial Agents
Potassium
Myenteric Plexus
Tetrodotoxin
Adenosine Triphosphatases
Shock
primycin

ASJC Scopus subject areas

  • Pharmacology

Cite this

Acetylcholine-releasing effect of primycin, a highly active antibiotic. / Ádám-Vizi, V.; Horvath, I.; Vízi, E.

In: Pharmacology, Vol. 20, No. 5, 1980, p. 268-274.

Research output: Contribution to journalArticle

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