Acetone is a volatile, flammable liquid. It is rapidly absorbed by inhalation, ingestion, and dermally, and distributed throughout the body. Once acetone has been absorbed, it is metabolized, but the pharmacokinetics and the selection of metabolic pathway seem to be dose dependent. Excretion of acetone appears in breath and urine. Inhaled acetone is narcotic and causes transient central nervous system effects, but it is not a neurotoxicant. In occupational environments, workers exposed to acetone for weeks do not exhibit long-lasting complaints. Acetone is neither genotoxic nor mutagenic. As it now looks, acetone is hazardous because of its potentiating effect on the toxicity of other volatile organic solvents and methylglyoxal.
|Title of host publication||Encyclopedia of Toxicology|
|Subtitle of host publication||Third Edition|
|Number of pages||4|
|Publication status||Published - Jan 1 2014|
- Ketogenic diet
- γ-Aminobutyric acid
ASJC Scopus subject areas