Acetone

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

Acetone is a volatile, flammable liquid. It is rapidly absorbed by inhalation, ingestion, and dermally, and distributed throughout the body. Once acetone has been absorbed, it is metabolized, but the pharmacokinetics and the selection of metabolic pathway seem to be dose dependent. Excretion of acetone appears in breath and urine. Inhaled acetone is narcotic and causes transient central nervous system effects, but it is not a neurotoxicant. In occupational environments, workers exposed to acetone for weeks do not exhibit long-lasting complaints. Acetone is neither genotoxic nor mutagenic. As it now looks, acetone is hazardous because of its potentiating effect on the toxicity of other volatile organic solvents and methylglyoxal.

Original languageEnglish
Title of host publicationEncyclopedia of Toxicology
Subtitle of host publicationThird Edition
PublisherElsevier
Pages36-39
Number of pages4
ISBN (Electronic)9780123864543
ISBN (Print)9780123864550
DOIs
Publication statusPublished - Jan 1 2014

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Keywords

  • Acetoacetate
  • Carcinogenicity
  • Cumene
  • CYPIIE1
  • Genotoxicity
  • Isopropanol
  • Ketogenic diet
  • LD
  • Methylglyoxal
  • Propanediol
  • γ-Aminobutyric acid

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kalapos, M. (2014). Acetone. In Encyclopedia of Toxicology: Third Edition (pp. 36-39). Elsevier. https://doi.org/10.1016/B978-0-12-386454-3.00995-7