ACE gene polymorphism and renal scarring in primary vesicoureteric reflux

I. Haszon, Aaron L. Friedman, Ferenc Papp, C. Bereczki, Sándor Baji, Tibor Bodrogi, Éva Károly, E. Endreffy, S. Túri

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The objective of this study was to investigate whether mutations of the renin-angiotensin system genes are involved in primary vesicoureteric reflux (VUR) and VUR-associated renal scarring. The M235T polymorphism of the angiotensinogen (ATG) gene, the I/D polymorphism of the angiotensin converting enzyme (ACE) gene, and the A1166C polymorphism of the angiotensin II grade 1 receptor (AT1) gene were identified in 77 patients with primary VUR (aged 6.9±3.2 years, mean±SD) and 80 healthy controls (aged 33±7 years). Thirty-eight of the 77 VUR patients had high-grade VUR (grade I-III) and 39 had high-grade VUR (grade IV and V). Renal scarring was found in 43 VUR patients, while 34 patients had normal kidneys on dinercaptosuccinic acid scan. The ACE gene polymorphism has determined by polymerase chain reaction and the ATG and AT1 gene polymorphisms were determined by single-step LightCycler technology. We found significant over-representation of the DD genotype in patients with renal scarring (44%) compared with normal controls (23%, P

Original languageEnglish
Pages (from-to)1027-1031
Number of pages5
JournalPediatric Nephrology
Volume17
Issue number12
DOIs
Publication statusPublished - 2002

Fingerprint

Peptidyl-Dipeptidase A
Cicatrix
Kidney
Genes
Angiotensinogen
Renin-Angiotensin System
Angiotensin II
Genotype
Technology
Polymerase Chain Reaction
Mutation
Acids

Keywords

  • Angiotensin converting ezyme
  • Angiotensin II type 1 receptor
  • Angiotensinogen
  • LightCycler technology
  • Polymorphism
  • Renal scarring
  • Vesicoureteric reflux

ASJC Scopus subject areas

  • Nephrology
  • Pediatrics, Perinatology, and Child Health

Cite this

ACE gene polymorphism and renal scarring in primary vesicoureteric reflux. / Haszon, I.; Friedman, Aaron L.; Papp, Ferenc; Bereczki, C.; Baji, Sándor; Bodrogi, Tibor; Károly, Éva; Endreffy, E.; Túri, S.

In: Pediatric Nephrology, Vol. 17, No. 12, 2002, p. 1027-1031.

Research output: Contribution to journalArticle

Haszon, I. ; Friedman, Aaron L. ; Papp, Ferenc ; Bereczki, C. ; Baji, Sándor ; Bodrogi, Tibor ; Károly, Éva ; Endreffy, E. ; Túri, S. / ACE gene polymorphism and renal scarring in primary vesicoureteric reflux. In: Pediatric Nephrology. 2002 ; Vol. 17, No. 12. pp. 1027-1031.
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