Accuracy of in vivo carotid B-mode ultrasound compared with pathological analysis intima-media thickening, lumen diameter, and cross-sectional area

Gernot Schulte-Altedorneburg, Dirk W. Droste, Szabolcs Felszeghy, Mónika Kellermann, Vasile Popa, Katalin Hegedüs, Csaba Hegedüs, Martina Schmid, László Módis, E. Bernd Ringelstein, László Csiba

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Abstract

Background and Purpose - This study aimed to determine the correlation of in vivo ultrasound measurements of intima-media thickening (IMT), lumen diameter, and cross-sectional area of the common carotid artery (CCA) with corresponding measurements obtained by gross pathology and histology. Methods - Sixty-six moribund neurological patients (mean age 71 years) underwent B-mode ultrasound of the CCA a few days before death. During autopsy, carotid specimens were removed in toto. Carotid arteries were ligated and cannulated for injection of a hydrophilic embedding material under standardized conditions. The carotid bifurcation was frozen and cut manually in 3-mm cross slices. Digital image analysis was carried out to determine the diameter and the cross-sectional area of the frozen slices of the CCA. IMT was assessed by light microscope. Ultrasonic and planimetric data were compared. Results - Mean measurements of lumen diameter and cross-sectional area were 7.13±1.27 mm and 0.496±0.167 cm2, respectively, by ultrasound, and 7.81±1.45 mm and 0.516±0.194 cm2, respectively, by planimetric analysis of the unfixed redistended carotid arteries (R2=0.389 and 0.497). The mean IMT was 1.005±0.267 mm by ultrasound and 0.67±0.141 mm histologically, resulting in a mean difference of -31%. Conclusions - Transcutaneous B-mode ultrasound provides a reliable approach for in vivo measurements of the cross-sectional area and, less exactly, of the lumen diameter of the CCA. Compared with histological results, in vivo ultrasound measurements of the IMT are systematically larger.

Original languageEnglish
Pages (from-to)1520-1524
Number of pages5
JournalStroke
Volume32
Issue number7
DOIs
Publication statusPublished - Jan 1 2001

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Keywords

  • Carotid arteries
  • Pathology
  • Ultrasonography

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialised Nursing

Cite this

Schulte-Altedorneburg, G., Droste, D. W., Felszeghy, S., Kellermann, M., Popa, V., Hegedüs, K., Hegedüs, C., Schmid, M., Módis, L., Ringelstein, E. B., & Csiba, L. (2001). Accuracy of in vivo carotid B-mode ultrasound compared with pathological analysis intima-media thickening, lumen diameter, and cross-sectional area. Stroke, 32(7), 1520-1524. https://doi.org/10.1161/01.STR.32.7.1520