Accumulation of heat-labile elongation factor 2 in the liver of mice and rats

Ryoya Takahashi, Nozomu Mori, Sataro Goto

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Age-related changes of polypeptide chain elongation factor 2 (EF-2) in mouse and rat livers were investigated. The percentage of heat-labile components in EF-2 was 5 to 10% in young animals and 15 to 40% in old ones. These results and other findings (Takahashi et al., in press) support the idea that decrease in translational activity in old animals is due, in part, to alterations of protein components of the translational system.

Original languageEnglish
Pages (from-to)325-331
Number of pages7
JournalExperimental gerontology
Issue number6
Publication statusPublished - 1985


ASJC Scopus subject areas

  • Biochemistry
  • Ageing
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Cell Biology

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