Accumulation of aluminum in rat brain: Does it lead to behavioral and electrophysiological changes?

Terken Baydar, A. Papp, Ahmet Aydin, L. Nagymajtényi, Horst Schulz, Askin Isimer, Gonul Sahin

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The present study was undertaken to examine possible aluminum (Al) accumulation in the brain of rats and to investigate whether subchronic exposure to the metal leads to behavioral and neurophysiological changes in both treated and control groups. Each of the groups consisted of 10 animals. Aluminum chloride (AlCl3) at a low (50 mg/kg/d) or high (200 mg/kg/d) dose was applied to male Wistar rats by gavage for 8 wk. Al-free water by gavage was given to the control group throughout the experiment. Behavioral effects were evaluated by open-field (OF) motor activity and by acoustic startle response (ASR). Electrophysiological examination was done by recording spontaneous activity and sensory-evoked potentials from the visual, somatosensory, as well as auditory cortex. The Al content of each whole brain was determined by electrothermal atomic absorption spectrophotometry. Subchronic Al exposure slightly caused some changes in the evoked potentials and electrocorticograms and in the OF and ASR performance, but these results were not statistically significant. The brain Al levels of the control and the low and high dose of Al-exposed groups were measured as 0.717±0.208 μg/g (wet weight), 0.963±0.491 μg/g (wet weight) and 1.816±1.157 μg/g (wet weight), respectively.

Original languageEnglish
Pages (from-to)231-244
Number of pages14
JournalBiological Trace Element Research
Volume92
Issue number3
DOIs
Publication statusPublished - Jun 2003

Fingerprint

Aluminum
Rats
Brain
Startle Reflex
Bioelectric potentials
Evoked Potentials
Acoustics
Weights and Measures
Atomic Spectrophotometry
Control Groups
Auditory Cortex
Somatosensory Cortex
Spectrophotometry
Visual Cortex
Wistar Rats
Animals
Motor Activity
Metals
Water
Experiments

Keywords

  • Aluminum
  • Behavior
  • Electrophysiology
  • Rat
  • Subchronic intake

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Accumulation of aluminum in rat brain : Does it lead to behavioral and electrophysiological changes? / Baydar, Terken; Papp, A.; Aydin, Ahmet; Nagymajtényi, L.; Schulz, Horst; Isimer, Askin; Sahin, Gonul.

In: Biological Trace Element Research, Vol. 92, No. 3, 06.2003, p. 231-244.

Research output: Contribution to journalArticle

Baydar, Terken ; Papp, A. ; Aydin, Ahmet ; Nagymajtényi, L. ; Schulz, Horst ; Isimer, Askin ; Sahin, Gonul. / Accumulation of aluminum in rat brain : Does it lead to behavioral and electrophysiological changes?. In: Biological Trace Element Research. 2003 ; Vol. 92, No. 3. pp. 231-244.
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