Akcelerált parciális konformális külsö emlöbesugárzás emlömegtartó mûtét után - fázis II prospektív klinikai vizsgálat elözetes eredményei

Translated title of the contribution: Accelerated partial breast irradiation with three-dimensional conformal external beam radiotherapy following breast-conserving surgery - Preliminary results of a phase II clinical study

Mozsa Emöke, C. Polgár, Frohlich Georgina, T. Major, Janvary Levente, Lovey Katalin, Z. Sulyok, Takacsi Nagy Laszlo, J. Fodor, M. Kásler

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The aim of the study was to implement accelerated partial breast irradiation (APBI) by means of three-dimensional conformal radiotherapy (3D-CRT) following breast-conserving surgery (BCS) for early-stage breast cancer. Between December 2006 and February 2011, in 45 cases of low-risk, stage I-II breast cancer the tumour bed was marked with titanium clips during BCS. Postoperative APBI was given by means of 3D-CRT using 3 to 5 non-coplanar fields. The total dose of APBI was 36.9 Gy (9 x 4.1 Gy) using a twice-a-day fractionation over 5 consecutive days. Early and late radiation side effects and cosmetic results were analysed for the first 30 patients with a minimum follow-up of 1 year. At a mean follow-up of 25.2 months neither loco-regional nor distant failure was observed. Excellent, good, fair, and poor cosmetic outcome was detected in 10 (33.3%), 16 (53.4%), 4 (13.3%), and 0 (0%) patients, respectively. Grade 2 or worse acute side effect was not observed. Grade 1 fibrosis, grade 2 teleangiectasia and asymptomatic fat necrosis occurred in 4 (13.3%), 1 (3.3%) and 5 (16.7%) patients, respectively. No grade 3-4 late side effects were detected. 3D-CRT is a reproducible and feasible technique for the delivery of APBI following conservative surgery for the treatment of low-risk, early-stage invasive breast carcinoma. The preliminary results are promising, early- and mid-term radiation side effects are rare, and cosmetic results are excellent.

Original languageHungarian
Pages (from-to)235-241
Number of pages7
JournalMagyar Onkologia
Volume56
Issue number4
Publication statusPublished - 2012

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Segmental Mastectomy
Breast
Radiotherapy
Cosmetics
Breast Neoplasms
Radiation Effects
Fat Necrosis
Conformal Radiotherapy
Titanium
Surgical Instruments
Fibrosis
Clinical Studies

ASJC Scopus subject areas

  • Oncology

Cite this

Akcelerált parciális konformális külsö emlöbesugárzás emlömegtartó mûtét után - fázis II prospektív klinikai vizsgálat elözetes eredményei. / Emöke, Mozsa; Polgár, C.; Georgina, Frohlich; Major, T.; Levente, Janvary; Katalin, Lovey; Sulyok, Z.; Laszlo, Takacsi Nagy; Fodor, J.; Kásler, M.

In: Magyar Onkologia, Vol. 56, No. 4, 2012, p. 235-241.

Research output: Contribution to journalArticle

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abstract = "The aim of the study was to implement accelerated partial breast irradiation (APBI) by means of three-dimensional conformal radiotherapy (3D-CRT) following breast-conserving surgery (BCS) for early-stage breast cancer. Between December 2006 and February 2011, in 45 cases of low-risk, stage I-II breast cancer the tumour bed was marked with titanium clips during BCS. Postoperative APBI was given by means of 3D-CRT using 3 to 5 non-coplanar fields. The total dose of APBI was 36.9 Gy (9 x 4.1 Gy) using a twice-a-day fractionation over 5 consecutive days. Early and late radiation side effects and cosmetic results were analysed for the first 30 patients with a minimum follow-up of 1 year. At a mean follow-up of 25.2 months neither loco-regional nor distant failure was observed. Excellent, good, fair, and poor cosmetic outcome was detected in 10 (33.3{\%}), 16 (53.4{\%}), 4 (13.3{\%}), and 0 (0{\%}) patients, respectively. Grade 2 or worse acute side effect was not observed. Grade 1 fibrosis, grade 2 teleangiectasia and asymptomatic fat necrosis occurred in 4 (13.3{\%}), 1 (3.3{\%}) and 5 (16.7{\%}) patients, respectively. No grade 3-4 late side effects were detected. 3D-CRT is a reproducible and feasible technique for the delivery of APBI following conservative surgery for the treatment of low-risk, early-stage invasive breast carcinoma. The preliminary results are promising, early- and mid-term radiation side effects are rare, and cosmetic results are excellent.",
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AU - Polgár, C.

AU - Georgina, Frohlich

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AU - Levente, Janvary

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