Absorption of epidermal growth factor occurs through the gastrointestinal tract and oral cavity in adult rats

K. R. Purushotham, K. Offenmuller, A. T. Bui, T. Zelles, J. Blazsek, G. S. Schultz, M. G. Humphreys-Beher

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Introduction of radiolabeled epidermal growth factor (125I-EGF) by garage or sublingual confinement resulted in a time-dependent uptake and systemic organ dissemination in the adult rat. Intact EGF was recovered primarily from the tongue, parotid, and sublingual/submandibular glands after administration by sublingual lozenge, whereas gastrointestinal administration resulted in 125I-EGF recovery primarily from plasma, stomach, and lung. Recovered radiolabeled EGF retained the ability to bind to the EGF receptor. Sialoadenectomy caused an increase in 125I-EGF in most tissues by both routes of administration. Thus, in the adult rat, at least two pathways exist for the uptake and distribution for salivary gland-derived EGF present in saliva. With further analyses, sublingual absorbance of EGF may therefore provide a potential delivery route for therapeutic use of growth factor, which avoids the hepatic destruction of EGF after oral administration.

Original languageEnglish
Pages (from-to)G867-G873
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume269
Issue number6 32-6
DOIs
Publication statusPublished - 1995

Keywords

  • aging
  • drug delivery
  • growth factors
  • saliva
  • salivary glands

ASJC Scopus subject areas

  • Physiology
  • Hepatology
  • Gastroenterology
  • Physiology (medical)

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