1. The absorption and urinary excretion of oxyphencyclimine HCI was studied in patients before and after a prolonged oxyphencyclimine treatment. The unmetabolized drug in the patients’ urine was bioassaid after both oral and parenteral administration of the drug. 2. Oxyphencyclimine was absorbed quickly and excreted in the urine 12 to 16 h after both its oral and parenteral administration. The oral-parenteral dose ratio was found to be 2 to 4: 1 before a prolonged treatment. 3. The results showed that the metabolization and urinary excretion of the drug did not change depending on a prolonged (from one and a half months to one year) oxyphencyclimine treatment, but the absorption increased significantly. 4. The human pharmacodynamic problems of the prolonged anticholinergic treatment are discussed.
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