Absorption and urinary excretion of oxyphencyclimine HCl in patients before and afterb a prolonged oxyphencyclimine treatment

Gy Mózsik, A. Berstad, J. Myren, J. Setekleiv

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5 Citations (Scopus)

Abstract

1. The absorption and urinary excretion of oxyphencyclimine HCI was studied in patients before and after a prolonged oxyphencyclimine treatment. The unmetabolized drug in the patients’ urine was bioassaid after both oral and parenteral administration of the drug. 2. Oxyphencyclimine was absorbed quickly and excreted in the urine 12 to 16 h after both its oral and parenteral administration. The oral-parenteral dose ratio was found to be 2 to 4: 1 before a prolonged treatment. 3. The results showed that the metabolization and urinary excretion of the drug did not change depending on a prolonged (from one and a half months to one year) oxyphencyclimine treatment, but the absorption increased significantly. 4. The human pharmacodynamic problems of the prolonged anticholinergic treatment are discussed.

Original languageEnglish
Pages (from-to)10-16
Number of pages7
JournalPharmacology
Volume19
Issue number1
DOIs
Publication statusPublished - Jan 1 1969

ASJC Scopus subject areas

  • Pharmacology

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