Cottonogenic in situ derivatives of potential ligands with different transition metal complexes containing 2 or 3 metal atoms have been used for the purpose of 1) obtaining CD-bands from non-absorbing compounds, and 2) to force flexible molecules into one preferred conformation. Natural products whose stereochemistry can be investigated in this way are e.g. acids, glycols, amines, aminoalcohols, diamines, peptides and nucleoside derivatives. From the Cotton effects the absolute conformations or even absolute configurations can be obtained with the help of empirical rules.
ASJC Scopus subject areas
- Chemical Engineering(all)