Absolute configuration of in situ transition metal complexes of ligating natural products from circular dichroism

Jadwiga Frelek, Zsuzsa Majer, Anna Perkowska, Günther Snatzke, Ioncho Vlahov, Ulrich Wagner

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Abstract

Cottonogenic in situ derivatives of potential ligands with different transition metal complexes containing 2 or 3 metal atoms have been used for the purpose of 1) obtaining CD-bands from non-absorbing compounds, and 2) to force flexible molecules into one preferred conformation. Natural products whose stereochemistry can be investigated in this way are e.g. acids, glycols, amines, aminoalcohols, diamines, peptides and nucleoside derivatives. From the Cotton effects the absolute conformations or even absolute configurations can be obtained with the help of empirical rules.

Original languageEnglish
Pages (from-to)441-451
Number of pages11
JournalPure and Applied Chemistry
Volume57
Issue number3
DOIs
Publication statusPublished - Jan 1 1985

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ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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