Abnormal motor activity and thermoregulation in a schizophrenia rat model for translational science

G. Horváth, G. Kékesi, Zita Petrovszki, G. Benedek

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: Schizophrenia is accompanied by altered motor activity and abnormal thermoregulation; therefore, the presence of these symptoms can enhance the face validity of a schizophrenia animal model. The goal was to characterize these parameters in freely moving condition of a new substrain of rats showing several schizophrenia-related alterations. Methods: Male Wistar rats were used: the new substrain housed individually (for four weeks) and treated subchronically with ketamine, and naive animals without any manipulations. Adult animals were implanted with E-Mitter transponders intraabdominally to record body temperature and locomotor activity continuously. The circadian rhythm of these parameters and the acute effects of changes in light conditions were analyzed under undisturbed circumstances, and the effects of different interventions (handling, bed changing or intraperitoneal vehicle injection) were also determined. Results: Decreased motor activity with fragmented pattern was observed in the new substrain. However, these animals had higher body temperature during the active phase, and they showed wider range of its alterations, too. The changes in light conditions and different interventions produced blunted hyperactivity and altered body temperature responses in the new substrain. Poincaré plot analysis of body temperature revealed enhanced short- and long-term variabilities during the active phase compared to the inactive phase in both groups. Furthermore, the new substrain showed increased short- and long-term variabilities with lower degree of asymmetry suggesting autonomic dysregulation. Conclusions: In summary, the new substrain with schizophrenia-related phenomena showed disturbed motor activity and thermoregulation suggesting that these objectively determined parameters can be biomarkers in translational research.

Original languageEnglish
Article number0143751
JournalPLoS One
Volume10
Issue number12
DOIs
Publication statusPublished - Dec 1 2015

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Body Temperature Regulation
thermoregulation
Body Temperature
body temperature
Rats
Schizophrenia
Animals
Motor Activity
animal models
Light
Temperature
transponders
Translational Medical Research
Transponders
rats
acute effects
Ketamine
ketamine
Biomarkers
Locomotion

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Abnormal motor activity and thermoregulation in a schizophrenia rat model for translational science. / Horváth, G.; Kékesi, G.; Petrovszki, Zita; Benedek, G.

In: PLoS One, Vol. 10, No. 12, 0143751, 01.12.2015.

Research output: Contribution to journalArticle

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