Low density liporotein receptorok kóros müködése hypercholesterinaemiában szenvedö betegek monocytáiban.

Translated title of the contribution: Abnormal function of lipoprotein receptors in the monocytes of hypercholesteremic patients

G. Paragh, Z. Varga, M. Szabolcs, E. Kovács, Z. Balogh, G. Fóris

Research output: Contribution to journalArticle

Abstract

The familial hypercholesterinemia (HCh) is as a genetically determined disorder. The genetical damage and functional abnormalities of the LDL receptors lead to familial Hch. The LDL plays an important role in cholesterol metabolism. They carry cholesterol which metabolizes through specific and scavenger LDL receptors. The ApoB100 particle of LDL binds to the receptors, internalizated, and digested, and the remaining free cholesterol regulates the intracellular cholesterol synthesis. It inhibits the key enzyme, HMG-CoA reductase and decreases the LDL receptor synthesis and increases cholesterol esterification. These mechanism can prevent the cholesterol accumulation of the cells. The aim of the present study was to clarify the activity and number of the LDL receptor, to study the LDL binding and degradation and to evaluate how the intracellular cholesterol can regulate the synthesis in patients with HCh. 58 pts with HCh and their monocytes were investigated, because the monocyte derived macrophages contained both specific and scavenger receptors. Monocytes of the pts were compared to the healthy individual controls. From the results it could be recognized--that the decreased binding to the specific LDL receptors only at 6 pts cholesterol synthesis was elevated in HCh pts group, while the synthesis inhibition induced by 50 micrograms LDL was decreased. The presented experimental results suggested that the decreased binding ability to LDL receptors is a rare cause of cholesterol abnormalities, while during the intracellular degradation process more metabolic steps can be damaged in patients with HCh.

Translated title of the contributionAbnormal function of lipoprotein receptors in the monocytes of hypercholesteremic patients
Original languageHungarian
Pages (from-to)2298-2301
Number of pages4
JournalOrvosi hetilap
Volume138
Issue number36 Suppl 2
Publication statusPublished - Sep 7 1997

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Abnormal function of lipoprotein receptors in the monocytes of hypercholesteremic patients'. Together they form a unique fingerprint.

  • Cite this