Abnormal cardiovascular autonomic regulation in Parkinson's disease

Tamás Szili-Török, L. Rudas, G. Dibó, D. Paprika, A. Kardos

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Parkinson's disease (PD) is often associated with an autonomic neuropathy. The extent of autonomic involvement, however is poorly defined and unpredictable. In order to assess the autonomic cardiovascular regulation time and frequency domain indices of heart rate and frequency domain indices of blood pressure the variability was determined non-invasively in 20 patients (age: 66 ± 8 years) with PD. The arbitrarily chosen level of spontaneous linear baroreflex sensitivity (BRS) of 3.5 ms/mmHg served to divide PD patients into subgroups. 12 PD patients exhibited a normal (nBRS), and 8 an impaired (iBRS) BRS. The results were compared with those from 18 healthy age-matched volunteers. The group of iBRS PD patients exhibited marked abnormalities in the other indices of cardiovascular autonomic regulation. In contrast, nBRS PD patients displayed only modest deviations. It is concluded that a decreased BRS is a distinctive feature of the impaired cardiovascular autonomic regulation in this heterogeneous population, and may serve as a selection marker for further assessment.

Original languageEnglish
Pages (from-to)245-247
Number of pages3
JournalJournal of Clinical and Basic Cardiology
Volume2
Issue number2
Publication statusPublished - Dec 1 1999

Keywords

  • Baroreflex sensitivity
  • Parkinson's disease

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Abnormal cardiovascular autonomic regulation in Parkinson's disease'. Together they form a unique fingerprint.

  • Cite this