Ability of different rescue therapies to save the bowel in acute, severe, steroid-refractory ulcerative colitis

Klaudia Farkas, Tamás Molnár, Zoltán Szepes

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

To date, corticosteroids have been the primary therapies for acute, severe ulcerative colitis (UC). Patients not responding to intravenous steroids assessed at 3-5 days of the treatment are candidates for second-line rescue therapy. Cyclosporine (CsA), tacrolimus and infliximab (IFX) are also effective therapeutic options in acute, severe UC. In this review we summarized the results of the published studies examining and comparing the efficacy of CsA, tacrolimus and IFX as rescue therapies, and assessing the outcome of switching the drugs in case of therapeutic failure.

Original languageEnglish
Pages (from-to)695-702
Number of pages8
JournalExpert Review of Gastroenterology and Hepatology
Volume8
Issue number6
DOIs
Publication statusPublished - Aug 2014

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Keywords

  • acute ulcerative colitis
  • cyclosporine
  • infliximab
  • rescue therapy
  • tacrolimus

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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