Aberrations in post-trauma monocyte (Mø) subpopulation: Role in septic shock syndrome

Carol L. Miller-Graziano, G. Szabó, Karen Kodys, Katherine Griffey

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Appearance of increased proportions of monocytes bearing the 72kd(FcRI) receptor for IgG correlated to aberrant monocyte (Mø) functions, depressed immune functions, and poor clinical outcome. The trauma patients’ FeRI+Mø subpopulation produced the majority of their elevated IL-6, TNFα, TGFβand PGE2, IgG stimulation of patients’ Mø through FeRI not only stimulated TNFα, IL-6, and PGE2levels, but also greatly augmented the levls of these monokines produced after subsequent bacterial challenge. Post-trauma increased IL-6 levels can lead to polyclonal E-cell activation and high levels of circulating, nonspecific IgG as seen in trauma patients. This nonspecific IgG triggers the FeRI on the increased numbers of FeRI+Mø leading to ever-increasing monokine levels. IL-4 was found to downregulate patients’ FeRI+Mø production of mediators. The cycle of altered cytokine levels, increased FeRI+Mø numbers, elevated IgG, and augmented triggering of FeRI+Mø may be broken by addition of IL-4.

Original languageEnglish
Pages (from-to)S86-S97
JournalJournal of Trauma - Injury, Infection and Critical Care
Volume30
Issue number12
Publication statusPublished - 1990

Fingerprint

Septic Shock
Monocytes
Immunoglobulin G
Monokines
Interleukin-6
Wounds and Injuries
Interleukin-4
IgG Receptors
Dinoprostone
Down-Regulation
Cytokines

ASJC Scopus subject areas

  • Surgery
  • Critical Care and Intensive Care Medicine

Cite this

Aberrations in post-trauma monocyte (Mø) subpopulation : Role in septic shock syndrome. / Miller-Graziano, Carol L.; Szabó, G.; Kodys, Karen; Griffey, Katherine.

In: Journal of Trauma - Injury, Infection and Critical Care, Vol. 30, No. 12, 1990, p. S86-S97.

Research output: Contribution to journalArticle

Miller-Graziano, Carol L. ; Szabó, G. ; Kodys, Karen ; Griffey, Katherine. / Aberrations in post-trauma monocyte (Mø) subpopulation : Role in septic shock syndrome. In: Journal of Trauma - Injury, Infection and Critical Care. 1990 ; Vol. 30, No. 12. pp. S86-S97.
@article{11c0e60ad820480db509a8d02e535ccd,
title = "Aberrations in post-trauma monocyte (M{\o}) subpopulation: Role in septic shock syndrome",
abstract = "Appearance of increased proportions of monocytes bearing the 72kd(FcRI) receptor for IgG correlated to aberrant monocyte (M{\o}) functions, depressed immune functions, and poor clinical outcome. The trauma patients’ FeRI+M{\o} subpopulation produced the majority of their elevated IL-6, TNFα, TGFβand PGE2, IgG stimulation of patients’ M{\o} through FeRI not only stimulated TNFα, IL-6, and PGE2levels, but also greatly augmented the levls of these monokines produced after subsequent bacterial challenge. Post-trauma increased IL-6 levels can lead to polyclonal E-cell activation and high levels of circulating, nonspecific IgG as seen in trauma patients. This nonspecific IgG triggers the FeRI on the increased numbers of FeRI+M{\o} leading to ever-increasing monokine levels. IL-4 was found to downregulate patients’ FeRI+M{\o} production of mediators. The cycle of altered cytokine levels, increased FeRI+M{\o} numbers, elevated IgG, and augmented triggering of FeRI+M{\o} may be broken by addition of IL-4.",
author = "Miller-Graziano, {Carol L.} and G. Szab{\'o} and Karen Kodys and Katherine Griffey",
year = "1990",
language = "English",
volume = "30",
pages = "S86--S97",
journal = "Journal of Trauma and Acute Care Surgery",
issn = "2163-0755",
publisher = "Lippincott Williams and Wilkins",
number = "12",

}

TY - JOUR

T1 - Aberrations in post-trauma monocyte (Mø) subpopulation

T2 - Role in septic shock syndrome

AU - Miller-Graziano, Carol L.

AU - Szabó, G.

AU - Kodys, Karen

AU - Griffey, Katherine

PY - 1990

Y1 - 1990

N2 - Appearance of increased proportions of monocytes bearing the 72kd(FcRI) receptor for IgG correlated to aberrant monocyte (Mø) functions, depressed immune functions, and poor clinical outcome. The trauma patients’ FeRI+Mø subpopulation produced the majority of their elevated IL-6, TNFα, TGFβand PGE2, IgG stimulation of patients’ Mø through FeRI not only stimulated TNFα, IL-6, and PGE2levels, but also greatly augmented the levls of these monokines produced after subsequent bacterial challenge. Post-trauma increased IL-6 levels can lead to polyclonal E-cell activation and high levels of circulating, nonspecific IgG as seen in trauma patients. This nonspecific IgG triggers the FeRI on the increased numbers of FeRI+Mø leading to ever-increasing monokine levels. IL-4 was found to downregulate patients’ FeRI+Mø production of mediators. The cycle of altered cytokine levels, increased FeRI+Mø numbers, elevated IgG, and augmented triggering of FeRI+Mø may be broken by addition of IL-4.

AB - Appearance of increased proportions of monocytes bearing the 72kd(FcRI) receptor for IgG correlated to aberrant monocyte (Mø) functions, depressed immune functions, and poor clinical outcome. The trauma patients’ FeRI+Mø subpopulation produced the majority of their elevated IL-6, TNFα, TGFβand PGE2, IgG stimulation of patients’ Mø through FeRI not only stimulated TNFα, IL-6, and PGE2levels, but also greatly augmented the levls of these monokines produced after subsequent bacterial challenge. Post-trauma increased IL-6 levels can lead to polyclonal E-cell activation and high levels of circulating, nonspecific IgG as seen in trauma patients. This nonspecific IgG triggers the FeRI on the increased numbers of FeRI+Mø leading to ever-increasing monokine levels. IL-4 was found to downregulate patients’ FeRI+Mø production of mediators. The cycle of altered cytokine levels, increased FeRI+Mø numbers, elevated IgG, and augmented triggering of FeRI+Mø may be broken by addition of IL-4.

UR - http://www.scopus.com/inward/record.url?scp=0025600867&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025600867&partnerID=8YFLogxK

M3 - Article

C2 - 2254998

AN - SCOPUS:0025600867

VL - 30

SP - S86-S97

JO - Journal of Trauma and Acute Care Surgery

JF - Journal of Trauma and Acute Care Surgery

SN - 2163-0755

IS - 12

ER -