Aberrant transcriptional regulatory network in T cells of multiple sclerosis

Jun ichi Satoh, Zsolt Illes, Agnes Peterfalvi, Hiroko Tabunoki, Csilla Rozsa, Takashi Yamamura

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

To identify the molecular network of the genes deregulated in multiple sclerosis (MS), we studied gene expression profile of purified CD3+ T cells isolated from Hungarian monozygotic MS twins by DNA microarray analysis. By comparing three concordant and one discordant pairs, we identified 20 differentially expressed genes (DEG) between the MS patient and the genetically identical healthy subject. Molecular network of 20 DEG analyzed by KeyMolnet, a comprehensive information platform, indicated the close relationship with transcriptional regulation by the Ets transcription factor family and the nuclear factor NF-κB. This novel bioinformatic approach proposes the logical hypothesis that aberrant regulation of the complex transcriptional regulatory network contributes to development of pathogenic T cells in MS.

Original languageEnglish
Pages (from-to)30-33
Number of pages4
JournalNeuroscience Letters
Volume422
Issue number1
DOIs
Publication statusPublished - Jul 5 2007

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Gene Regulatory Networks
Multiple Sclerosis
T-Lymphocytes
Proto-Oncogene Proteins c-ets
Microarray Analysis
Oligonucleotide Array Sequence Analysis
Computational Biology
Nuclear Family
Transcriptome
Genes
Healthy Volunteers

Keywords

  • KeyMolnet
  • Microarray
  • Monozygotic twin
  • Multiple sclerosis
  • T cells
  • Transcriptional regulation

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Aberrant transcriptional regulatory network in T cells of multiple sclerosis. / Satoh, Jun ichi; Illes, Zsolt; Peterfalvi, Agnes; Tabunoki, Hiroko; Rozsa, Csilla; Yamamura, Takashi.

In: Neuroscience Letters, Vol. 422, No. 1, 05.07.2007, p. 30-33.

Research output: Contribution to journalArticle

Satoh, JI, Illes, Z, Peterfalvi, A, Tabunoki, H, Rozsa, C & Yamamura, T 2007, 'Aberrant transcriptional regulatory network in T cells of multiple sclerosis', Neuroscience Letters, vol. 422, no. 1, pp. 30-33. https://doi.org/10.1016/j.neulet.2007.05.056
Satoh, Jun ichi ; Illes, Zsolt ; Peterfalvi, Agnes ; Tabunoki, Hiroko ; Rozsa, Csilla ; Yamamura, Takashi. / Aberrant transcriptional regulatory network in T cells of multiple sclerosis. In: Neuroscience Letters. 2007 ; Vol. 422, No. 1. pp. 30-33.
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