Abd-A regulation by the iab-8 noncoding RNA

Maheshwar Gummalla, Robert K. Maeda, Javier J. Alvarez, Henrik Gyurkovics, Swetha Singari, Kevin A. Edwards, François Karch, Welcome Bender

Research output: Contribution to journalArticle

46 Citations (Scopus)


The homeotic genes in Drosophila melanogaster are aligned on the chromosome in the order of the body segments that they affect. The genes affecting the more posterior segments repress the more anterior genes. This posterior dominance rule must be qualified in the case of abdominal-A (abd-A) repression by Abdominal-B (Abd-B). Animals lacking Abd-B show ectopic expression of abd-A in the epidermis of the eighth abdominal segment, but not in the central nervous system. Repression in these neuronal cells is accomplished by a 92 kb noncoding RNA. This "iab-8 RNA" produces a micro RNA to repress abd-A, but also has a second, redundant repression mechanism that acts only "in cis." Transcriptional interference with the abd-A promoter is the most likely mechanism.

Original languageEnglish
Article numbere1002720
JournalPLoS genetics
Issue number5
Publication statusPublished - May 2012

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics
  • Genetics(clinical)
  • Cancer Research

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    Gummalla, M., Maeda, R. K., Alvarez, J. J., Gyurkovics, H., Singari, S., Edwards, K. A., Karch, F., & Bender, W. (2012). Abd-A regulation by the iab-8 noncoding RNA. PLoS genetics, 8(5), [e1002720]. https://doi.org/10.1371/journal.pgen.1002720