ABCC6 as a target in pseudoxanthoma elasticum

A. Váradi, Z. Szabó, Viola Pomozi, Hugues de Boussac, Krisztina Fülöp, T. Arányi

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The ABCC6 gene encodes an organic anion transporter protein, ABCC6/MRP6. Mutations in the gene cause a rare, recessive genetic disease, pseudoxanthoma elasticum, while the loss of one ABCC6 allele is a genetic risk factor in coronary artery disease. We review here the information available on gene structure, evolution as well as the present knowledge on its transcriptional regulation. We give a detailed description of the characteristics of the protein, and analyze the relationship between the distributions of missense disease-causing mutations in the predicted three-dimensional structure of the transporter, which suggests functional importance of the domain-domain interactions. Though neither the physiological function of the protein nor its role in the pathobiology of the diseases are known, a current hypothesis that ABCC6 may be involved in the efflux of one form of Vitamin K from the liver is discussed. Finally, we analyze potential strategies how the gene can be targeted on the transcriptional level to increase protein expression in order to compensate for reduced activity. In addition, pharmacologic correction of trafficking-defect mutants or suppression of stop codon mutations as potential future therapeutic interventions are also reviewed.

Original languageEnglish
Pages (from-to)671-682
Number of pages12
JournalCurrent Drug Targets
Volume12
Issue number5
DOIs
Publication statusPublished - 2011

Fingerprint

Pseudoxanthoma Elasticum
Rubber
Genes
Mutation
Proteins
Organic Anion Transporters
Inborn Genetic Diseases
Vitamin K
Terminator Codon
Liver
Coronary Artery Disease
Alleles
Defects

Keywords

  • Calcification
  • Cardiovascular
  • Connective tissue
  • Genetic disease
  • Homology model
  • Membrane proteins
  • Transcriptional regulation
  • Vitamin K

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Clinical Biochemistry
  • Molecular Medicine

Cite this

ABCC6 as a target in pseudoxanthoma elasticum. / Váradi, A.; Szabó, Z.; Pomozi, Viola; de Boussac, Hugues; Fülöp, Krisztina; Arányi, T.

In: Current Drug Targets, Vol. 12, No. 5, 2011, p. 671-682.

Research output: Contribution to journalArticle

Váradi, A. ; Szabó, Z. ; Pomozi, Viola ; de Boussac, Hugues ; Fülöp, Krisztina ; Arányi, T. / ABCC6 as a target in pseudoxanthoma elasticum. In: Current Drug Targets. 2011 ; Vol. 12, No. 5. pp. 671-682.
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