ABCC2/Abcc2: A multispecific transporter with dominant excretory functions

K. Jemnitz, Krisztina Heredi-Szabo, Judit Janossy, Eniko Ioja, L. Vereczkey, Peter Krajcsi

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

ABCC2/Abcc2 (MRP2/Mrp2) is expressed at major physiological barriers, such as the canalicular membrane of liver cells, kidney proximal tubule epithelial cells, enterocytes of the small and large intestine, and syncytiotrophoblast of the placenta. ABCC2/Abcc2 always localizes in the apical membranes. Although ABCC2/Abcc2 transports a variety of amphiphilic anions that belong to different classes of molecules, such as endogenous compounds (e.g., bilirubin- glucuronides), drugs, toxic chemicals, nutraceuticals, and their conjugates, it displays a preference for phase II conjugates. Phenotypically, the most obvious consequence of mutations in ABCC2 that lead to Dubin-Johnson syndrome is conjugate hyperbilirubinemia. ABCC2/Abcc2 harbors multiple binding sites and displays complex transport kinetics.

Original languageEnglish
Pages (from-to)402-436
Number of pages35
JournalDrug Metabolism Reviews
Volume42
Issue number3
DOIs
Publication statusPublished - 2010

Fingerprint

Chronic Idiopathic Jaundice
Proximal Kidney Tubule
Hyperbilirubinemia
Enterocytes
Poisons
Large Intestine
Trophoblasts
Dietary Supplements
Placenta
Small Intestine
Anions
Epithelial Cells
Binding Sites
Cell Membrane
Mutation
Membranes
Liver
Pharmaceutical Preparations
bilirubin glucuronate

Keywords

  • ABC transporter
  • ABCC2
  • ADME
  • Conjugate hyperbilirubinemia
  • Dubin-Johnson syndrome
  • MRP2
  • Pharmacokinetics
  • Toxicity

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Medicine(all)

Cite this

ABCC2/Abcc2 : A multispecific transporter with dominant excretory functions. / Jemnitz, K.; Heredi-Szabo, Krisztina; Janossy, Judit; Ioja, Eniko; Vereczkey, L.; Krajcsi, Peter.

In: Drug Metabolism Reviews, Vol. 42, No. 3, 2010, p. 402-436.

Research output: Contribution to journalArticle

Jemnitz, K. ; Heredi-Szabo, Krisztina ; Janossy, Judit ; Ioja, Eniko ; Vereczkey, L. ; Krajcsi, Peter. / ABCC2/Abcc2 : A multispecific transporter with dominant excretory functions. In: Drug Metabolism Reviews. 2010 ; Vol. 42, No. 3. pp. 402-436.
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