ABCC1 polymorphisms in anthracycline-induced cardiotoxicity in childhood acute lymphoblastic leukaemia

Agnes F. Semsei, Daniel J. Erdelyi, Ildiko Ungvari, Edit Csagoly, Marta Z. Hegyi, Petra S. Kiszel, Orsolya Lautner-Csorba, Judit Szabolcs, Peter Masat, G. Fekete, A. Falus, C. Szalai, Gabor T. Kovacs

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Anthracyclines are potent cytostatic drugs, the correct dosage being critical to avoid possible cardiac side effects. ABCC1 [ATP-binding cassette, sub-family C, member 1; also denoted as MRP1 (multidrug resistance-associated protein 1)] is expressed in the heart and takes part in the detoxification and protection of cells from the toxic effects of xenobiotics, including anthracyclines. Our objective was to search for associations between LV (left ventricular) function and single-nucleotide polymorphisms of the ABCC1 gene in children receiving anthracycline chemotherapy. Data of 235 paediatric patients with acute lymphoblastic leukaemia was analysed. Patients were followed-up by echocardiography (median follow-up 6.3 years). Nine polymorphisms in the ABCC1 gene were genotyped. The ABCC1 rs3743527TT genotype and rs3743527TT-rs246221TC/TT genotype combination were associated with lower LVFS (left ventricular fractional shortening) after chemotherapy. The results suggest that genetic variants in the ABCC1 gene influence anthracycline-induced LV dysfunction.

Original languageEnglish
Pages (from-to)79-86
Number of pages8
JournalCell Biology International
Volume36
Issue number1
DOIs
Publication statusPublished - Jan 2012

Fingerprint

Anthracyclines
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Genotype
Genes
Drug Therapy
Cytoprotection
Poisons
Cytostatic Agents
Left Ventricular Dysfunction
Xenobiotics
Left Ventricular Function
Single Nucleotide Polymorphism
Echocardiography
Adenosine Triphosphate
Pediatrics
Cardiotoxicity

Keywords

  • ABCC1
  • Cardiotoxicity
  • Fractional shortening
  • Leukaemia
  • Pharmacogenetics
  • Side effects

ASJC Scopus subject areas

  • Cell Biology

Cite this

Semsei, A. F., Erdelyi, D. J., Ungvari, I., Csagoly, E., Hegyi, M. Z., Kiszel, P. S., ... Kovacs, G. T. (2012). ABCC1 polymorphisms in anthracycline-induced cardiotoxicity in childhood acute lymphoblastic leukaemia. Cell Biology International, 36(1), 79-86. https://doi.org/10.1042/CBI20110264

ABCC1 polymorphisms in anthracycline-induced cardiotoxicity in childhood acute lymphoblastic leukaemia. / Semsei, Agnes F.; Erdelyi, Daniel J.; Ungvari, Ildiko; Csagoly, Edit; Hegyi, Marta Z.; Kiszel, Petra S.; Lautner-Csorba, Orsolya; Szabolcs, Judit; Masat, Peter; Fekete, G.; Falus, A.; Szalai, C.; Kovacs, Gabor T.

In: Cell Biology International, Vol. 36, No. 1, 01.2012, p. 79-86.

Research output: Contribution to journalArticle

Semsei, AF, Erdelyi, DJ, Ungvari, I, Csagoly, E, Hegyi, MZ, Kiszel, PS, Lautner-Csorba, O, Szabolcs, J, Masat, P, Fekete, G, Falus, A, Szalai, C & Kovacs, GT 2012, 'ABCC1 polymorphisms in anthracycline-induced cardiotoxicity in childhood acute lymphoblastic leukaemia', Cell Biology International, vol. 36, no. 1, pp. 79-86. https://doi.org/10.1042/CBI20110264
Semsei, Agnes F. ; Erdelyi, Daniel J. ; Ungvari, Ildiko ; Csagoly, Edit ; Hegyi, Marta Z. ; Kiszel, Petra S. ; Lautner-Csorba, Orsolya ; Szabolcs, Judit ; Masat, Peter ; Fekete, G. ; Falus, A. ; Szalai, C. ; Kovacs, Gabor T. / ABCC1 polymorphisms in anthracycline-induced cardiotoxicity in childhood acute lymphoblastic leukaemia. In: Cell Biology International. 2012 ; Vol. 36, No. 1. pp. 79-86.
@article{da8ecd85720d42909d289be3eff08224,
title = "ABCC1 polymorphisms in anthracycline-induced cardiotoxicity in childhood acute lymphoblastic leukaemia",
abstract = "Anthracyclines are potent cytostatic drugs, the correct dosage being critical to avoid possible cardiac side effects. ABCC1 [ATP-binding cassette, sub-family C, member 1; also denoted as MRP1 (multidrug resistance-associated protein 1)] is expressed in the heart and takes part in the detoxification and protection of cells from the toxic effects of xenobiotics, including anthracyclines. Our objective was to search for associations between LV (left ventricular) function and single-nucleotide polymorphisms of the ABCC1 gene in children receiving anthracycline chemotherapy. Data of 235 paediatric patients with acute lymphoblastic leukaemia was analysed. Patients were followed-up by echocardiography (median follow-up 6.3 years). Nine polymorphisms in the ABCC1 gene were genotyped. The ABCC1 rs3743527TT genotype and rs3743527TT-rs246221TC/TT genotype combination were associated with lower LVFS (left ventricular fractional shortening) after chemotherapy. The results suggest that genetic variants in the ABCC1 gene influence anthracycline-induced LV dysfunction.",
keywords = "ABCC1, Cardiotoxicity, Fractional shortening, Leukaemia, Pharmacogenetics, Side effects",
author = "Semsei, {Agnes F.} and Erdelyi, {Daniel J.} and Ildiko Ungvari and Edit Csagoly and Hegyi, {Marta Z.} and Kiszel, {Petra S.} and Orsolya Lautner-Csorba and Judit Szabolcs and Peter Masat and G. Fekete and A. Falus and C. Szalai and Kovacs, {Gabor T.}",
year = "2012",
month = "1",
doi = "10.1042/CBI20110264",
language = "English",
volume = "36",
pages = "79--86",
journal = "Cell Biology International",
issn = "1065-6995",
publisher = "Portland Press Ltd.",
number = "1",

}

TY - JOUR

T1 - ABCC1 polymorphisms in anthracycline-induced cardiotoxicity in childhood acute lymphoblastic leukaemia

AU - Semsei, Agnes F.

AU - Erdelyi, Daniel J.

AU - Ungvari, Ildiko

AU - Csagoly, Edit

AU - Hegyi, Marta Z.

AU - Kiszel, Petra S.

AU - Lautner-Csorba, Orsolya

AU - Szabolcs, Judit

AU - Masat, Peter

AU - Fekete, G.

AU - Falus, A.

AU - Szalai, C.

AU - Kovacs, Gabor T.

PY - 2012/1

Y1 - 2012/1

N2 - Anthracyclines are potent cytostatic drugs, the correct dosage being critical to avoid possible cardiac side effects. ABCC1 [ATP-binding cassette, sub-family C, member 1; also denoted as MRP1 (multidrug resistance-associated protein 1)] is expressed in the heart and takes part in the detoxification and protection of cells from the toxic effects of xenobiotics, including anthracyclines. Our objective was to search for associations between LV (left ventricular) function and single-nucleotide polymorphisms of the ABCC1 gene in children receiving anthracycline chemotherapy. Data of 235 paediatric patients with acute lymphoblastic leukaemia was analysed. Patients were followed-up by echocardiography (median follow-up 6.3 years). Nine polymorphisms in the ABCC1 gene were genotyped. The ABCC1 rs3743527TT genotype and rs3743527TT-rs246221TC/TT genotype combination were associated with lower LVFS (left ventricular fractional shortening) after chemotherapy. The results suggest that genetic variants in the ABCC1 gene influence anthracycline-induced LV dysfunction.

AB - Anthracyclines are potent cytostatic drugs, the correct dosage being critical to avoid possible cardiac side effects. ABCC1 [ATP-binding cassette, sub-family C, member 1; also denoted as MRP1 (multidrug resistance-associated protein 1)] is expressed in the heart and takes part in the detoxification and protection of cells from the toxic effects of xenobiotics, including anthracyclines. Our objective was to search for associations between LV (left ventricular) function and single-nucleotide polymorphisms of the ABCC1 gene in children receiving anthracycline chemotherapy. Data of 235 paediatric patients with acute lymphoblastic leukaemia was analysed. Patients were followed-up by echocardiography (median follow-up 6.3 years). Nine polymorphisms in the ABCC1 gene were genotyped. The ABCC1 rs3743527TT genotype and rs3743527TT-rs246221TC/TT genotype combination were associated with lower LVFS (left ventricular fractional shortening) after chemotherapy. The results suggest that genetic variants in the ABCC1 gene influence anthracycline-induced LV dysfunction.

KW - ABCC1

KW - Cardiotoxicity

KW - Fractional shortening

KW - Leukaemia

KW - Pharmacogenetics

KW - Side effects

UR - http://www.scopus.com/inward/record.url?scp=84862565294&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862565294&partnerID=8YFLogxK

U2 - 10.1042/CBI20110264

DO - 10.1042/CBI20110264

M3 - Article

VL - 36

SP - 79

EP - 86

JO - Cell Biology International

JF - Cell Biology International

SN - 1065-6995

IS - 1

ER -