ABCB1 C3435T Polymorphism Influences the Risk for Alzheimer’s Disease

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

To evaluate the association of ATP-binding cassette subfamily B member 1 (ABCB1) genetic variants with the susceptibility to Alzheimer’s disease (AD), we genotyped the rs1128503 (C1236T), rs2032582 (G2677T/A), and rs1045642 (C3435T) polymorphisms in a case–control sample (234 AD patients, 225 controls). Single-marker analyses revealed a significant association solely for the rs1045642 polymorphism (C/C genotype carriers had increased risk for AD), which remains significant after correction for multiple testing. Haplotype analyses indicated three nominally significant associations which were lost after applying multiple test correction.

Original languageEnglish
Pages (from-to)826-829
Number of pages4
JournalJournal of Molecular Neuroscience
Volume54
Issue number4
DOIs
Publication statusPublished - Nov 26 2014

Fingerprint

Alzheimer Disease
Adenosine Triphosphate
Haplotypes
Genotype

Keywords

  • Alzheimer’s disease
  • ATP-binding cassette subfamily B member 1 (ABCB1)
  • P-glycoprotein (P-gp)
  • rs1045642 (C3435T)
  • rs1128503 (C1236T)
  • rs2032582 (G2677T/A)
  • Single nucleotide polymorphism (SNP)

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Medicine(all)

Cite this

ABCB1 C3435T Polymorphism Influences the Risk for Alzheimer’s Disease. / Fehér, Ágnes; Juhász, A.; Pákáski, M.; Kálmán, J.; Janka, Z.

In: Journal of Molecular Neuroscience, Vol. 54, No. 4, 26.11.2014, p. 826-829.

Research output: Contribution to journalArticle

@article{f2c5cf7e442d42bd9708bac70bad300e,
title = "ABCB1 C3435T Polymorphism Influences the Risk for Alzheimer’s Disease",
abstract = "To evaluate the association of ATP-binding cassette subfamily B member 1 (ABCB1) genetic variants with the susceptibility to Alzheimer’s disease (AD), we genotyped the rs1128503 (C1236T), rs2032582 (G2677T/A), and rs1045642 (C3435T) polymorphisms in a case–control sample (234 AD patients, 225 controls). Single-marker analyses revealed a significant association solely for the rs1045642 polymorphism (C/C genotype carriers had increased risk for AD), which remains significant after correction for multiple testing. Haplotype analyses indicated three nominally significant associations which were lost after applying multiple test correction.",
keywords = "Alzheimer’s disease, ATP-binding cassette subfamily B member 1 (ABCB1), P-glycoprotein (P-gp), rs1045642 (C3435T), rs1128503 (C1236T), rs2032582 (G2677T/A), Single nucleotide polymorphism (SNP)",
author = "{\'A}gnes Feh{\'e}r and A. Juh{\'a}sz and M. P{\'a}k{\'a}ski and J. K{\'a}lm{\'a}n and Z. Janka",
year = "2014",
month = "11",
day = "26",
doi = "10.1007/s12031-014-0427-z",
language = "English",
volume = "54",
pages = "826--829",
journal = "Journal of Molecular Neuroscience",
issn = "0895-8696",
publisher = "Humana Press",
number = "4",

}

TY - JOUR

T1 - ABCB1 C3435T Polymorphism Influences the Risk for Alzheimer’s Disease

AU - Fehér, Ágnes

AU - Juhász, A.

AU - Pákáski, M.

AU - Kálmán, J.

AU - Janka, Z.

PY - 2014/11/26

Y1 - 2014/11/26

N2 - To evaluate the association of ATP-binding cassette subfamily B member 1 (ABCB1) genetic variants with the susceptibility to Alzheimer’s disease (AD), we genotyped the rs1128503 (C1236T), rs2032582 (G2677T/A), and rs1045642 (C3435T) polymorphisms in a case–control sample (234 AD patients, 225 controls). Single-marker analyses revealed a significant association solely for the rs1045642 polymorphism (C/C genotype carriers had increased risk for AD), which remains significant after correction for multiple testing. Haplotype analyses indicated three nominally significant associations which were lost after applying multiple test correction.

AB - To evaluate the association of ATP-binding cassette subfamily B member 1 (ABCB1) genetic variants with the susceptibility to Alzheimer’s disease (AD), we genotyped the rs1128503 (C1236T), rs2032582 (G2677T/A), and rs1045642 (C3435T) polymorphisms in a case–control sample (234 AD patients, 225 controls). Single-marker analyses revealed a significant association solely for the rs1045642 polymorphism (C/C genotype carriers had increased risk for AD), which remains significant after correction for multiple testing. Haplotype analyses indicated three nominally significant associations which were lost after applying multiple test correction.

KW - Alzheimer’s disease

KW - ATP-binding cassette subfamily B member 1 (ABCB1)

KW - P-glycoprotein (P-gp)

KW - rs1045642 (C3435T)

KW - rs1128503 (C1236T)

KW - rs2032582 (G2677T/A)

KW - Single nucleotide polymorphism (SNP)

UR - http://www.scopus.com/inward/record.url?scp=84914117900&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84914117900&partnerID=8YFLogxK

U2 - 10.1007/s12031-014-0427-z

DO - 10.1007/s12031-014-0427-z

M3 - Article

C2 - 25273678

AN - SCOPUS:84914117900

VL - 54

SP - 826

EP - 829

JO - Journal of Molecular Neuroscience

JF - Journal of Molecular Neuroscience

SN - 0895-8696

IS - 4

ER -