ABCA1 polymorphism, a genetic risk factor of harm avoidance

Eszter Kotyuk, Viktor Biro, Julianna Bircher, Zsuzsanna Elek, Maria Sasvari, Anna Szekely

Research output: Contribution to journalArticle

Abstract

Even though cholesterol homeostasis and self-harm behaviors have shown to be associated, gene polymorphisms of the cholesterol system have not been studied yet in the context of self-harm related personality traits. Here we present an association study between six ABCA1 polymorphisms and temperament scales measured by Cloninger's Temperament and Character Inventory on 253 young adults. An association between ABCA1 rs4149264 and harm avoidance has been observed. This association remained significant after Bonferroni correction. Haplotype analysis confirmed an independent association between rs4149264 and harm avoidance. ABCA1, a cholesterol homeostasis gene, is a candidate gene for harm related personality traits.

Original languageEnglish
Pages (from-to)189-195
Number of pages7
JournalJournal of Individual Differences
Volume38
Issue number3
DOIs
Publication statusPublished - Jul 2017

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Keywords

  • ABCA1 gene polymorphisms
  • Genetic association
  • Harm avoidance
  • Personality
  • Suicidal behavior

ASJC Scopus subject areas

  • Psychology(all)
  • Biological Psychiatry

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