A Wide Spectrum of Ocular Manifestations Signify Patients with Systemic Sclerosis

Gabriella Szucs, Zoltan Szekanecz, Zsuzsa Aszalos, Rudolf Gesztelyi, Judit Zsuga, Peter Szodoray, Adam Kemeny-Beke

Research output: Contribution to journalArticle


Objectives: Systemic sclerosis (SSc) is a rare, chronic connective tissue disease involving multiple organ systems, including the eye. We evaluated the detailed clinical ocular manifestations of outpatients with SSc. Methods: Demographics, disease duration and subtype, nailfold capillaroscopy (NFC) patterns and laboratory parameters encompassing the autoantibody profile of 51 SSc patients were evaluated, and a general ocular examination was performed for each participant. Results: Twenty-nine patients (56.86%) had eyelid skin alterations, 26 (50.98%) had retinal abnormalities, 26 (50.98%) had cataracts, 8 (15.69%) had conjunctival changes, 7 (13.73%) had iris abnormalities, 33 (64.71%) suffered from dry eye disease (DED), and 11 (21.57%) suffered from glaucoma. Significant positive correlations were found between NFC data and both tear breakup time and Ocular Surface Disease Index test values. Conclusions: Eyelid skin abnormalities, DED and retinal abnormalities are among the most common SSc-related ocular involvements. Diverse ophthalmic findings are attributed to the heterogeneity of SSc.

Original languageEnglish
JournalOcular Immunology and Inflammation
Publication statusAccepted/In press - Jan 1 2019



  • Dry eye disease
  • nailfold capillaroscopy
  • ocular findings
  • ocular manifestations
  • pathogenesis
  • scleroderma
  • systemic sclerosis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Ophthalmology

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