A very mild and quantitative oxidation of cephalosporins with dimethyldioxirane

Tamás E. Gunda, László Tamás, Szabolcs Sályi, Csaba Nemes, Ferenc Sztaricskai

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Abstract

The cephalosporins 1-3 and Δ2-cephem 4 were oxidized in quantative yields to their sulfones with dimethyldioxirane. While in the case of 2-methylene-cephems (5,6) the exocyclic double bond oxidized simultaneously to the corresponding epoxide, the 3-vinyl derivative (8) or 3-methylenecephems (7) gave selectively the corresponding vinyl sulfone.

Original languageEnglish
Pages (from-to)7111-7114
Number of pages4
JournalTetrahedron Letters
Volume36
Issue number39
DOIs
Publication statusPublished - Sep 25 1995

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ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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