Mono- and di-carboxylic acid derivatives of various structural isomers of the pyrrolidin-1-oxyl ring containing a stable free radical (spin label) can be obtained by Michael addition of a nitroalkane to an α,β-unsaturated ketone to give a γ-nitroketone, followed by ring closure to a pyrrolin-1-yl oxide which reacts with Grignard reagents to give a pyrrolidin-1-oxyl compound, which undergoes phase-transfer oxidation of its terminal unsaturated bond.
|Number of pages||3|
|Journal||Journal of the Chemical Society, Chemical Communications|
|Publication status||Published - Jan 1 1984|
ASJC Scopus subject areas
- Molecular Medicine