The authors adopted the angiographic osmotic blood-brain barrier opening method on pigs. During the angiography beside the previously experienced complications, new complications that unambiguously related to the BBB opening have not been occurred. They proved the reversible opening of BBB in the osmotic way by in vitro and in vivo methods (CT, MRI); the closing time was 30-60 minutes. During the MR examination USPIO structured iron content contrast agent was applied, which appeared in the brain after the osmotic BBB opening, thus it got through the BBB. Pig may be appropriate to further experiments of BBB, because despite the species specific rete mirabile, a relatively good side difference can be achieved in the point of BBB opening. The iron content MR contrast nanoparticle that get through the osmotically opened BBB proved that the new agent may be proper for the examination of central nervous system also in pigs.
|Number of pages||7|
|Journal||Magyar Allatorvosok Lapja|
|Publication status||Published - Apr 12 2012|
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