A two year global evaluation of the susceptibility of Candida species to fluconazole by disk diffusion

L. D. Liebowitz, H. R. Ashbee, E. G V Evans, Y. Chong, N. Mallatova, M. Zaidi, D. Gibbs, M. R. Costa, J. Finquelievich, D. Ellis, S. Chen, D. Frameree, A. Van den Abeele, J. M. Senterre, A. Colombo, C. Mendes, H. Bijie, M. Chen, M. Mendez, E. ChmelarovaJ. Ayabaca, J. M. Bastide, Cremer, H. Bernhardt, G. Petrikos, E. Puskás, M. K. Thege, I. Barcs, E. Nagy, N. Carlone, V. Tullio, G. C. Schito, O. Soro, G. Fortina, S. Andreoni, J. Igari, N. G. Kee Peng, C. Alpuche, J. Santos, J. F G M Meis, S. Zurita, D. Dzierzanowska, M. L. Martins, L. Stratchounski, M. Yeo, L. Oon, J. Trupl, D. Roditi, D. Pillay, A. Hoosen, H. H. Crewe-Brown, M. N J Van Rensbrug, A. Del Palacio, F. Baquero, B. Jonsson, J. Bille, S. C. Chang, P. Tharavichitkul, M. Vorachit, D. Gur, M. Petrou, N. Weightman, I. M. Gould, A. Santiago

Research output: Contribution to journalArticle

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Abstract

The in-vitro activity of fluconazole against 46,831 yeast isolates collected over a two-year period from 57 laboratories in 33 countries worldwide was assessed using a disc diffusion method. Candida albicans was the organism isolated most frequently, accounting for 68.6% of the total number of isolates. C. glabrata, C. tropicalis, C parapsilosis and C. krusei and Cryptococcus neoformans represented 9.9, 4.7, 4.3, 1.9, and 1.4% of isolates respectively during the 2 year period and rates varied markedly between countries. In 1999 data blood isolates represented 4.9% of all isolates and intensive care unit isolates represented 9.9%. In both the 1998 and 1999 data, 99% of C. albicans were fully susceptible (S) to fluconazole, and 95.6% of all species of yeasts tested were S or susceptible-dose dependent (S-DD) to fluconazole. No emerging trends of resistance were noted with any of the Candida spp. tested as 96% of all isolates retained susceptibility (S or S-DD) to this agent.

Original languageEnglish
Pages (from-to)27-33
Number of pages7
JournalDiagnostic Microbiology and Infectious Disease
Volume40
Issue number1-2
DOIs
Publication statusPublished - 2001

Fingerprint

Fluconazole
Candida
Candida albicans
Yeasts
Cryptococcus neoformans
Intensive Care Units

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy
  • Virology
  • Parasitology
  • Microbiology
  • Immunology
  • Applied Microbiology and Biotechnology

Cite this

Liebowitz, L. D., Ashbee, H. R., Evans, E. G. V., Chong, Y., Mallatova, N., Zaidi, M., ... Santiago, A. (2001). A two year global evaluation of the susceptibility of Candida species to fluconazole by disk diffusion. Diagnostic Microbiology and Infectious Disease, 40(1-2), 27-33. https://doi.org/10.1016/S0732-8893(01)00243-7

A two year global evaluation of the susceptibility of Candida species to fluconazole by disk diffusion. / Liebowitz, L. D.; Ashbee, H. R.; Evans, E. G V; Chong, Y.; Mallatova, N.; Zaidi, M.; Gibbs, D.; Costa, M. R.; Finquelievich, J.; Ellis, D.; Chen, S.; Frameree, D.; Van den Abeele, A.; Senterre, J. M.; Colombo, A.; Mendes, C.; Bijie, H.; Chen, M.; Mendez, M.; Chmelarova, E.; Ayabaca, J.; Bastide, J. M.; Cremer; Bernhardt, H.; Petrikos, G.; Puskás, E.; Thege, M. K.; Barcs, I.; Nagy, E.; Carlone, N.; Tullio, V.; Schito, G. C.; Soro, O.; Fortina, G.; Andreoni, S.; Igari, J.; Kee Peng, N. G.; Alpuche, C.; Santos, J.; Meis, J. F G M; Zurita, S.; Dzierzanowska, D.; Martins, M. L.; Stratchounski, L.; Yeo, M.; Oon, L.; Trupl, J.; Roditi, D.; Pillay, D.; Hoosen, A.; Crewe-Brown, H. H.; Van Rensbrug, M. N J; Del Palacio, A.; Baquero, F.; Jonsson, B.; Bille, J.; Chang, S. C.; Tharavichitkul, P.; Vorachit, M.; Gur, D.; Petrou, M.; Weightman, N.; Gould, I. M.; Santiago, A.

In: Diagnostic Microbiology and Infectious Disease, Vol. 40, No. 1-2, 2001, p. 27-33.

Research output: Contribution to journalArticle

Liebowitz, LD, Ashbee, HR, Evans, EGV, Chong, Y, Mallatova, N, Zaidi, M, Gibbs, D, Costa, MR, Finquelievich, J, Ellis, D, Chen, S, Frameree, D, Van den Abeele, A, Senterre, JM, Colombo, A, Mendes, C, Bijie, H, Chen, M, Mendez, M, Chmelarova, E, Ayabaca, J, Bastide, JM, Cremer, Bernhardt, H, Petrikos, G, Puskás, E, Thege, MK, Barcs, I, Nagy, E, Carlone, N, Tullio, V, Schito, GC, Soro, O, Fortina, G, Andreoni, S, Igari, J, Kee Peng, NG, Alpuche, C, Santos, J, Meis, JFGM, Zurita, S, Dzierzanowska, D, Martins, ML, Stratchounski, L, Yeo, M, Oon, L, Trupl, J, Roditi, D, Pillay, D, Hoosen, A, Crewe-Brown, HH, Van Rensbrug, MNJ, Del Palacio, A, Baquero, F, Jonsson, B, Bille, J, Chang, SC, Tharavichitkul, P, Vorachit, M, Gur, D, Petrou, M, Weightman, N, Gould, IM & Santiago, A 2001, 'A two year global evaluation of the susceptibility of Candida species to fluconazole by disk diffusion', Diagnostic Microbiology and Infectious Disease, vol. 40, no. 1-2, pp. 27-33. https://doi.org/10.1016/S0732-8893(01)00243-7
Liebowitz, L. D. ; Ashbee, H. R. ; Evans, E. G V ; Chong, Y. ; Mallatova, N. ; Zaidi, M. ; Gibbs, D. ; Costa, M. R. ; Finquelievich, J. ; Ellis, D. ; Chen, S. ; Frameree, D. ; Van den Abeele, A. ; Senterre, J. M. ; Colombo, A. ; Mendes, C. ; Bijie, H. ; Chen, M. ; Mendez, M. ; Chmelarova, E. ; Ayabaca, J. ; Bastide, J. M. ; Cremer ; Bernhardt, H. ; Petrikos, G. ; Puskás, E. ; Thege, M. K. ; Barcs, I. ; Nagy, E. ; Carlone, N. ; Tullio, V. ; Schito, G. C. ; Soro, O. ; Fortina, G. ; Andreoni, S. ; Igari, J. ; Kee Peng, N. G. ; Alpuche, C. ; Santos, J. ; Meis, J. F G M ; Zurita, S. ; Dzierzanowska, D. ; Martins, M. L. ; Stratchounski, L. ; Yeo, M. ; Oon, L. ; Trupl, J. ; Roditi, D. ; Pillay, D. ; Hoosen, A. ; Crewe-Brown, H. H. ; Van Rensbrug, M. N J ; Del Palacio, A. ; Baquero, F. ; Jonsson, B. ; Bille, J. ; Chang, S. C. ; Tharavichitkul, P. ; Vorachit, M. ; Gur, D. ; Petrou, M. ; Weightman, N. ; Gould, I. M. ; Santiago, A. / A two year global evaluation of the susceptibility of Candida species to fluconazole by disk diffusion. In: Diagnostic Microbiology and Infectious Disease. 2001 ; Vol. 40, No. 1-2. pp. 27-33.
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abstract = "The in-vitro activity of fluconazole against 46,831 yeast isolates collected over a two-year period from 57 laboratories in 33 countries worldwide was assessed using a disc diffusion method. Candida albicans was the organism isolated most frequently, accounting for 68.6{\%} of the total number of isolates. C. glabrata, C. tropicalis, C parapsilosis and C. krusei and Cryptococcus neoformans represented 9.9, 4.7, 4.3, 1.9, and 1.4{\%} of isolates respectively during the 2 year period and rates varied markedly between countries. In 1999 data blood isolates represented 4.9{\%} of all isolates and intensive care unit isolates represented 9.9{\%}. In both the 1998 and 1999 data, 99{\%} of C. albicans were fully susceptible (S) to fluconazole, and 95.6{\%} of all species of yeasts tested were S or susceptible-dose dependent (S-DD) to fluconazole. No emerging trends of resistance were noted with any of the Candida spp. tested as 96{\%} of all isolates retained susceptibility (S or S-DD) to this agent.",
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T1 - A two year global evaluation of the susceptibility of Candida species to fluconazole by disk diffusion

AU - Liebowitz, L. D.

AU - Ashbee, H. R.

AU - Evans, E. G V

AU - Chong, Y.

AU - Mallatova, N.

AU - Zaidi, M.

AU - Gibbs, D.

AU - Costa, M. R.

AU - Finquelievich, J.

AU - Ellis, D.

AU - Chen, S.

AU - Frameree, D.

AU - Van den Abeele, A.

AU - Senterre, J. M.

AU - Colombo, A.

AU - Mendes, C.

AU - Bijie, H.

AU - Chen, M.

AU - Mendez, M.

AU - Chmelarova, E.

AU - Ayabaca, J.

AU - Bastide, J. M.

AU - Cremer,

AU - Bernhardt, H.

AU - Petrikos, G.

AU - Puskás, E.

AU - Thege, M. K.

AU - Barcs, I.

AU - Nagy, E.

AU - Carlone, N.

AU - Tullio, V.

AU - Schito, G. C.

AU - Soro, O.

AU - Fortina, G.

AU - Andreoni, S.

AU - Igari, J.

AU - Kee Peng, N. G.

AU - Alpuche, C.

AU - Santos, J.

AU - Meis, J. F G M

AU - Zurita, S.

AU - Dzierzanowska, D.

AU - Martins, M. L.

AU - Stratchounski, L.

AU - Yeo, M.

AU - Oon, L.

AU - Trupl, J.

AU - Roditi, D.

AU - Pillay, D.

AU - Hoosen, A.

AU - Crewe-Brown, H. H.

AU - Van Rensbrug, M. N J

AU - Del Palacio, A.

AU - Baquero, F.

AU - Jonsson, B.

AU - Bille, J.

AU - Chang, S. C.

AU - Tharavichitkul, P.

AU - Vorachit, M.

AU - Gur, D.

AU - Petrou, M.

AU - Weightman, N.

AU - Gould, I. M.

AU - Santiago, A.

PY - 2001

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