A two-step synthesis of ferrocenyl pyrazole and pyrimidine derivatives based on carbonylative Sonogashira coupling of iodoferrocene

Csaba Fehér, Árpád Kuik, László Márk, László Kollár, Rita Skoda-Földes

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25 Citations (Scopus)


A new method for the synthesis of 3-substituted-1-ferrocenyl-2-propyn-1-ones was developed involving carbonylative Sonogashira coupling of iodoferrocene with terminal acetylenes. New ferrocenyl 1,3,5-trisubstituted pyrazoles and 2,4,6-trisubstituted pyrimidines were obtained by the addition-cyclocondensation reaction of the alkynones with hydrazines and guanidinium salts, respectively. The products were obtained with moderate to excellent yields and were characterised with various spectroscopic methods (1H NMR, 13C NMR IR, MS).

Original languageEnglish
Pages (from-to)4036-4041
Number of pages6
JournalJournal of Organometallic Chemistry
Issue number25
Publication statusPublished - Dec 1 2009



  • Carbonylation
  • Ferrocene
  • Palladium
  • Pyrazole
  • Pyrimidine

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

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