A tumor-suppressor function for NFATc3 in T-cell lymphomagenesis by murine leukemia virus

Sys Zoffmann Glud, Annette Balle Sørensen, Mindaugas Andrulis, Bruce Wang, Eisaku Kondo, Randi Jessen, Laszlo Krenacs, Eva Stelkovics, Matthias Wabl, Edgar Serfling, Alois Palmetshofer, Finn Skou Pedersen

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Abstract

Nuclear factor of activated T cell (NFAT) transcription factors play a central role in differentiation, activation, and elimination of lymphocytes. We here report on the finding of provirus integration into the Nfatc3 locus in T-cell lymphomas induced by the murine lymphomagenic retrovirus SL3-3 and show that NFATc3 expression is repressed in these lymphomas. The provirus insertions are positioned close to the Nfatc3 promoter or a putative polyadenylated RNA (polyA) region. Furthermore, we demonstrate that NFATc3-deficient mice infected with SL3-3 develop T-cell lymphomas faster and with higher frequencies than wild-type mice or NFATc2-deficient mice. These results identify NFATc3 as a tumor suppressor for the development of murine T-cell lymphomas induced by the retrovirus SL3-3.

Original languageEnglish
Pages (from-to)3546-3552
Number of pages7
JournalBlood
Volume106
Issue number10
DOIs
Publication statusPublished - Nov 15 2005

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ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Cite this

Glud, S. Z., Sørensen, A. B., Andrulis, M., Wang, B., Kondo, E., Jessen, R., Krenacs, L., Stelkovics, E., Wabl, M., Serfling, E., Palmetshofer, A., & Pedersen, F. S. (2005). A tumor-suppressor function for NFATc3 in T-cell lymphomagenesis by murine leukemia virus. Blood, 106(10), 3546-3552. https://doi.org/10.1182/blood-2005-02-0493